Sarcomas After Inoculation of Newborn Hamsters with Herpes virus hominis Type 2 Strains (34945)

André J. Nahmias, Zuher M. Naib, William E. Josey, Frederick A. Murphy, Carolyn F. Luce

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Inoculation of newborn hamsters with virus doses greater than 103 TCD50 of types 1 or 2 Herpes virus hominis (HVH) strains caused a mortality approaching 100%. With lesser virus doses, nine sarcomas have been found 5–28 months after inoculation of four different noninactivated HVH type 2 strains and one other ultraviolet-inactivated type 2 strain. None of the animals inoculated with HVH type 1 strains developed tumors, and one newborn hamster inoculated intrathoracically with Eagle's MEM developed a cheek-pouch well-differentiated fibrosarcoma. Eight of the nine tumors with HVH type 2 strains were at or close to the site of inoculation and the histological characteristics of some of these tumors differ from those associated with other viral-induced hamster sarcomas. No clear-cut evidence of a relationship between HVH and the tumors by a variety of virological and serological assays has been obtained as yet. The finding of C-type particles in two of three tumors or their explants by electron microscopy has raised further questions about the role of HVH in the causation of the tumors found.

Original languageEnglish (US)
Pages (from-to)1065-1069
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume134
Issue number4
DOIs
StatePublished - Sep 1970

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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