SARS-associated Coronavirus Transmission, United States

Elmira T. Isakbaeva, Nino Khetsuriani, R. Suzanne Beard, Angela Peck, Dean Erdman, Stephan S. Monroe, Suxiang Tong, Thomas Ksiazek, Sara Lowther, Indra Pandya-Smith, Larry J. Anderson, Jairam Lingappa, Marc Alain Widdowson, J. McLaughlin, M. Romney, A. Kimura, D. Dassey, B. Lash, D. Terashita, S. KlishS. Cody, S. Farley, S. Lea, R. Sanderson, J. Wolthuis, C. Allard, B. Albanese, B. Nivin, P. McCall, M. Davies, M. Murphy, E. Koch, A. Weltman, H. Brumund, C. Barton, K. Whetstone, W. J. Bellini, S. Bialek, J. A. Comer, S. Emery, R. Helfand, T. Hennessy, A. James, A. LaMonte, E. C. Newbern, S. Scott, L. Simpson, A. Siwek, C. Smelser, L. Stockman, X. Lu, D. White

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalEmerging Infectious Diseases
Volume10
Issue number2
StatePublished - Feb 2004
Externally publishedYes

Fingerprint

SARS Virus
Severe Acute Respiratory Syndrome
Coronavirus
Sputum
Coronavirus Infections
Viruses

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Isakbaeva, E. T., Khetsuriani, N., Beard, R. S., Peck, A., Erdman, D., Monroe, S. S., ... White, D. (2004). SARS-associated Coronavirus Transmission, United States. Emerging Infectious Diseases, 10(2), 225-231.

SARS-associated Coronavirus Transmission, United States. / Isakbaeva, Elmira T.; Khetsuriani, Nino; Beard, R. Suzanne; Peck, Angela; Erdman, Dean; Monroe, Stephan S.; Tong, Suxiang; Ksiazek, Thomas; Lowther, Sara; Pandya-Smith, Indra; Anderson, Larry J.; Lingappa, Jairam; Widdowson, Marc Alain; McLaughlin, J.; Romney, M.; Kimura, A.; Dassey, D.; Lash, B.; Terashita, D.; Klish, S.; Cody, S.; Farley, S.; Lea, S.; Sanderson, R.; Wolthuis, J.; Allard, C.; Albanese, B.; Nivin, B.; McCall, P.; Davies, M.; Murphy, M.; Koch, E.; Weltman, A.; Brumund, H.; Barton, C.; Whetstone, K.; Bellini, W. J.; Bialek, S.; Comer, J. A.; Emery, S.; Helfand, R.; Hennessy, T.; James, A.; LaMonte, A.; Newbern, E. C.; Scott, S.; Simpson, L.; Siwek, A.; Smelser, C.; Stockman, L.; Lu, X.; White, D.

In: Emerging Infectious Diseases, Vol. 10, No. 2, 02.2004, p. 225-231.

Research output: Contribution to journalArticle

Isakbaeva, ET, Khetsuriani, N, Beard, RS, Peck, A, Erdman, D, Monroe, SS, Tong, S, Ksiazek, T, Lowther, S, Pandya-Smith, I, Anderson, LJ, Lingappa, J, Widdowson, MA, McLaughlin, J, Romney, M, Kimura, A, Dassey, D, Lash, B, Terashita, D, Klish, S, Cody, S, Farley, S, Lea, S, Sanderson, R, Wolthuis, J, Allard, C, Albanese, B, Nivin, B, McCall, P, Davies, M, Murphy, M, Koch, E, Weltman, A, Brumund, H, Barton, C, Whetstone, K, Bellini, WJ, Bialek, S, Comer, JA, Emery, S, Helfand, R, Hennessy, T, James, A, LaMonte, A, Newbern, EC, Scott, S, Simpson, L, Siwek, A, Smelser, C, Stockman, L, Lu, X & White, D 2004, 'SARS-associated Coronavirus Transmission, United States', Emerging Infectious Diseases, vol. 10, no. 2, pp. 225-231.
Isakbaeva ET, Khetsuriani N, Beard RS, Peck A, Erdman D, Monroe SS et al. SARS-associated Coronavirus Transmission, United States. Emerging Infectious Diseases. 2004 Feb;10(2):225-231.
Isakbaeva, Elmira T. ; Khetsuriani, Nino ; Beard, R. Suzanne ; Peck, Angela ; Erdman, Dean ; Monroe, Stephan S. ; Tong, Suxiang ; Ksiazek, Thomas ; Lowther, Sara ; Pandya-Smith, Indra ; Anderson, Larry J. ; Lingappa, Jairam ; Widdowson, Marc Alain ; McLaughlin, J. ; Romney, M. ; Kimura, A. ; Dassey, D. ; Lash, B. ; Terashita, D. ; Klish, S. ; Cody, S. ; Farley, S. ; Lea, S. ; Sanderson, R. ; Wolthuis, J. ; Allard, C. ; Albanese, B. ; Nivin, B. ; McCall, P. ; Davies, M. ; Murphy, M. ; Koch, E. ; Weltman, A. ; Brumund, H. ; Barton, C. ; Whetstone, K. ; Bellini, W. J. ; Bialek, S. ; Comer, J. A. ; Emery, S. ; Helfand, R. ; Hennessy, T. ; James, A. ; LaMonte, A. ; Newbern, E. C. ; Scott, S. ; Simpson, L. ; Siwek, A. ; Smelser, C. ; Stockman, L. ; Lu, X. ; White, D. / SARS-associated Coronavirus Transmission, United States. In: Emerging Infectious Diseases. 2004 ; Vol. 10, No. 2. pp. 225-231.
@article{39ca14f3285b4595ba5106ff6a5b9f5a,
title = "SARS-associated Coronavirus Transmission, United States",
abstract = "To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.",
author = "Isakbaeva, {Elmira T.} and Nino Khetsuriani and Beard, {R. Suzanne} and Angela Peck and Dean Erdman and Monroe, {Stephan S.} and Suxiang Tong and Thomas Ksiazek and Sara Lowther and Indra Pandya-Smith and Anderson, {Larry J.} and Jairam Lingappa and Widdowson, {Marc Alain} and J. McLaughlin and M. Romney and A. Kimura and D. Dassey and B. Lash and D. Terashita and S. Klish and S. Cody and S. Farley and S. Lea and R. Sanderson and J. Wolthuis and C. Allard and B. Albanese and B. Nivin and P. McCall and M. Davies and M. Murphy and E. Koch and A. Weltman and H. Brumund and C. Barton and K. Whetstone and Bellini, {W. J.} and S. Bialek and Comer, {J. A.} and S. Emery and R. Helfand and T. Hennessy and A. James and A. LaMonte and Newbern, {E. C.} and S. Scott and L. Simpson and A. Siwek and C. Smelser and L. Stockman and X. Lu and D. White",
year = "2004",
month = "2",
language = "English (US)",
volume = "10",
pages = "225--231",
journal = "Emerging Infectious Diseases",
issn = "1080-6040",
publisher = "Centers for Disease Control and Prevention (CDC)",
number = "2",

}

TY - JOUR

T1 - SARS-associated Coronavirus Transmission, United States

AU - Isakbaeva, Elmira T.

AU - Khetsuriani, Nino

AU - Beard, R. Suzanne

AU - Peck, Angela

AU - Erdman, Dean

AU - Monroe, Stephan S.

AU - Tong, Suxiang

AU - Ksiazek, Thomas

AU - Lowther, Sara

AU - Pandya-Smith, Indra

AU - Anderson, Larry J.

AU - Lingappa, Jairam

AU - Widdowson, Marc Alain

AU - McLaughlin, J.

AU - Romney, M.

AU - Kimura, A.

AU - Dassey, D.

AU - Lash, B.

AU - Terashita, D.

AU - Klish, S.

AU - Cody, S.

AU - Farley, S.

AU - Lea, S.

AU - Sanderson, R.

AU - Wolthuis, J.

AU - Allard, C.

AU - Albanese, B.

AU - Nivin, B.

AU - McCall, P.

AU - Davies, M.

AU - Murphy, M.

AU - Koch, E.

AU - Weltman, A.

AU - Brumund, H.

AU - Barton, C.

AU - Whetstone, K.

AU - Bellini, W. J.

AU - Bialek, S.

AU - Comer, J. A.

AU - Emery, S.

AU - Helfand, R.

AU - Hennessy, T.

AU - James, A.

AU - LaMonte, A.

AU - Newbern, E. C.

AU - Scott, S.

AU - Simpson, L.

AU - Siwek, A.

AU - Smelser, C.

AU - Stockman, L.

AU - Lu, X.

AU - White, D.

PY - 2004/2

Y1 - 2004/2

N2 - To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.

AB - To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.

UR - http://www.scopus.com/inward/record.url?scp=10744224740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744224740&partnerID=8YFLogxK

M3 - Article

C2 - 15030687

AN - SCOPUS:10744224740

VL - 10

SP - 225

EP - 231

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6040

IS - 2

ER -