SARS-associated Coronavirus Transmission, United States

Elmira T. Isakbaeva, Nino Khetsuriani, R. Suzanne Beard, Angela Peck, Dean Erdman, Stephan S. Monroe, Suxiang Tong, Thomas G. Ksiazek, Sara Lowther, Indra Pandya-Smith, Larry J. Anderson, Jairam Lingappa, Marc Alain Widdowson, J. McLaughlin, M. Romney, A. Kimura, D. Dassey, B. Lash, D. Terashita, S. KlishS. Cody, S. Farley, S. Lea, R. Sanderson, J. Wolthuis, C. Allard, B. Albanese, B. Nivin, P. McCall, M. Davies, M. Murphy, E. Koch, A. Weltman, H. Brumund, C. Barton, K. Whetstone, W. J. Bellini, S. Bialek, J. A. Comer, S. Emery, R. Helfand, T. Hennessy, A. James, A. LaMonte, E. C. Newbern, S. Scott, L. Simpson, A. Siwek, C. Smelser, L. Stockman, X. Lu, D. White

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalEmerging infectious diseases
Issue number2
StatePublished - Feb 2004
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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