Abstract
To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 225-231 |
| Number of pages | 7 |
| Journal | Emerging Infectious Diseases |
| Volume | 10 |
| Issue number | 2 |
| State | Published - Feb 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Microbiology (medical)
Cite this
SARS-associated Coronavirus Transmission, United States. / Isakbaeva, Elmira T.; Khetsuriani, Nino; Beard, R. Suzanne; Peck, Angela; Erdman, Dean; Monroe, Stephan S.; Tong, Suxiang; Ksiazek, Thomas; Lowther, Sara; Pandya-Smith, Indra; Anderson, Larry J.; Lingappa, Jairam; Widdowson, Marc Alain; McLaughlin, J.; Romney, M.; Kimura, A.; Dassey, D.; Lash, B.; Terashita, D.; Klish, S.; Cody, S.; Farley, S.; Lea, S.; Sanderson, R.; Wolthuis, J.; Allard, C.; Albanese, B.; Nivin, B.; McCall, P.; Davies, M.; Murphy, M.; Koch, E.; Weltman, A.; Brumund, H.; Barton, C.; Whetstone, K.; Bellini, W. J.; Bialek, S.; Comer, J. A.; Emery, S.; Helfand, R.; Hennessy, T.; James, A.; LaMonte, A.; Newbern, E. C.; Scott, S.; Simpson, L.; Siwek, A.; Smelser, C.; Stockman, L.; Lu, X.; White, D.
In: Emerging Infectious Diseases, Vol. 10, No. 2, 02.2004, p. 225-231.Research output: Contribution to journal › Article
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TY - JOUR
T1 - SARS-associated Coronavirus Transmission, United States
AU - Isakbaeva, Elmira T.
AU - Khetsuriani, Nino
AU - Beard, R. Suzanne
AU - Peck, Angela
AU - Erdman, Dean
AU - Monroe, Stephan S.
AU - Tong, Suxiang
AU - Ksiazek, Thomas
AU - Lowther, Sara
AU - Pandya-Smith, Indra
AU - Anderson, Larry J.
AU - Lingappa, Jairam
AU - Widdowson, Marc Alain
AU - McLaughlin, J.
AU - Romney, M.
AU - Kimura, A.
AU - Dassey, D.
AU - Lash, B.
AU - Terashita, D.
AU - Klish, S.
AU - Cody, S.
AU - Farley, S.
AU - Lea, S.
AU - Sanderson, R.
AU - Wolthuis, J.
AU - Allard, C.
AU - Albanese, B.
AU - Nivin, B.
AU - McCall, P.
AU - Davies, M.
AU - Murphy, M.
AU - Koch, E.
AU - Weltman, A.
AU - Brumund, H.
AU - Barton, C.
AU - Whetstone, K.
AU - Bellini, W. J.
AU - Bialek, S.
AU - Comer, J. A.
AU - Emery, S.
AU - Helfand, R.
AU - Hennessy, T.
AU - James, A.
AU - LaMonte, A.
AU - Newbern, E. C.
AU - Scott, S.
AU - Simpson, L.
AU - Siwek, A.
AU - Smelser, C.
AU - Stockman, L.
AU - Lu, X.
AU - White, D.
PY - 2004/2
Y1 - 2004/2
N2 - To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.
AB - To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.
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UR - http://www.scopus.com/inward/citedby.url?scp=10744224740&partnerID=8YFLogxK
M3 - Article
C2 - 15030687
AN - SCOPUS:10744224740
VL - 10
SP - 225
EP - 231
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
SN - 1080-6040
IS - 2
ER -