SARS-associated Coronavirus Transmission, United States

Elmira T. Isakbaeva; Nino Khetsuriani; R. Suzanne Beard; Angela Peck; Dean Erdman; Stephan S. Monroe; Suxiang Tong; Thomas G. Ksiazek; Sara Lowther; Indra Pandya-Smith; Larry J. Anderson; Jairam Lingappa; Marc Alain Widdowson; J. McLaughlin; M. Romney; A. Kimura; D. Dassey; B. Lash; D. Terashita; S. Klish; S. Cody; S. Farley; S. Lea; R. Sanderson; J. Wolthuis; C. Allard; B. Albanese; B. Nivin; P. McCall; M. Davies; M. Murphy; E. Koch; A. Weltman; H. Brumund; C. Barton; K. Whetstone; W. J. Bellini; S. Bialek; J. A. Comer; S. Emery; R. Helfand; T. Hennessy; A. James; A. LaMonte; E. C. Newbern; S. Scott; L. Simpson; A. Siwek; C. Smelser; L. Stockman; X. Lu; D. White

doi:10.3201/eid1002.030734

SARS-associated Coronavirus Transmission, United States

Elmira T. Isakbaeva, Nino Khetsuriani, R. Suzanne Beard, Angela Peck, Dean Erdman, Stephan S. Monroe, Suxiang Tong, Thomas G. Ksiazek, Sara Lowther, Indra Pandya-Smith, Larry J. Anderson, Jairam Lingappa, Marc Alain Widdowson, J. McLaughlin, M. Romney, A. Kimura, D. Dassey, B. Lash, D. Terashita, S. KlishS. Cody, S. Farley, S. Lea, R. Sanderson, J. Wolthuis, C. Allard, B. Albanese, B. Nivin, P. McCall, M. Davies, M. Murphy, E. Koch, A. Weltman, H. Brumund, C. Barton, K. Whetstone, W. J. Bellini, S. Bialek, J. A. Comer, S. Emery, R. Helfand, T. Hennessy, A. James, A. LaMonte, E. C. Newbern, S. Scott, L. Simpson, A. Siwek, C. Smelser, L. Stockman, X. Lu, D. White

Pathology

Research output: Contribution to journal › Article

27 Scopus citations

Abstract

To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.

Original language	English (US)
Pages (from-to)	225-231
Number of pages	7
Journal	Emerging infectious diseases
Volume	10
Issue number	2
DOIs	https://doi.org/10.3201/eid1002.030734
State	Published - Feb 2004

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

Access to Document

10.3201/eid1002.030734

Fingerprint Dive into the research topics of 'SARS-associated Coronavirus Transmission, United States'. Together they form a unique fingerprint.

Cite this

Isakbaeva, E. T., Khetsuriani, N., Beard, R. S., Peck, A., Erdman, D., Monroe, S. S., Tong, S., Ksiazek, T. G., Lowther, S., Pandya-Smith, I., Anderson, L. J., Lingappa, J., Widdowson, M. A., McLaughlin, J., Romney, M., Kimura, A., Dassey, D., Lash, B., Terashita, D., ... White, D. (2004). SARS-associated Coronavirus Transmission, United States. Emerging infectious diseases, 10(2), 225-231. https://doi.org/10.3201/eid1002.030734

SARS-associated Coronavirus Transmission, United States. / Isakbaeva, Elmira T.; Khetsuriani, Nino; Beard, R. Suzanne; Peck, Angela; Erdman, Dean; Monroe, Stephan S.; Tong, Suxiang; Ksiazek, Thomas G.; Lowther, Sara; Pandya-Smith, Indra; Anderson, Larry J.; Lingappa, Jairam; Widdowson, Marc Alain; McLaughlin, J.; Romney, M.; Kimura, A.; Dassey, D.; Lash, B.; Terashita, D.; Klish, S.; Cody, S.; Farley, S.; Lea, S.; Sanderson, R.; Wolthuis, J.; Allard, C.; Albanese, B.; Nivin, B.; McCall, P.; Davies, M.; Murphy, M.; Koch, E.; Weltman, A.; Brumund, H.; Barton, C.; Whetstone, K.; Bellini, W. J.; Bialek, S.; Comer, J. A.; Emery, S.; Helfand, R.; Hennessy, T.; James, A.; LaMonte, A.; Newbern, E. C.; Scott, S.; Simpson, L.; Siwek, A.; Smelser, C.; Stockman, L.; Lu, X.; White, D.

In: Emerging infectious diseases, Vol. 10, No. 2, 02.2004, p. 225-231.

Research output: Contribution to journal › Article

Isakbaeva, ET, Khetsuriani, N, Beard, RS, Peck, A, Erdman, D, Monroe, SS, Tong, S, Ksiazek, TG, Lowther, S, Pandya-Smith, I, Anderson, LJ, Lingappa, J, Widdowson, MA, McLaughlin, J, Romney, M, Kimura, A, Dassey, D, Lash, B, Terashita, D, Klish, S, Cody, S, Farley, S, Lea, S, Sanderson, R, Wolthuis, J, Allard, C, Albanese, B, Nivin, B, McCall, P, Davies, M, Murphy, M, Koch, E, Weltman, A, Brumund, H, Barton, C, Whetstone, K, Bellini, WJ, Bialek, S, Comer, JA, Emery, S, Helfand, R, Hennessy, T, James, A, LaMonte, A, Newbern, EC, Scott, S, Simpson, L, Siwek, A, Smelser, C, Stockman, L, Lu, X & White, D 2004, 'SARS-associated Coronavirus Transmission, United States', Emerging infectious diseases, vol. 10, no. 2, pp. 225-231. https://doi.org/10.3201/eid1002.030734

Isakbaeva, Elmira T. ; Khetsuriani, Nino ; Beard, R. Suzanne ; Peck, Angela ; Erdman, Dean ; Monroe, Stephan S. ; Tong, Suxiang ; Ksiazek, Thomas G. ; Lowther, Sara ; Pandya-Smith, Indra ; Anderson, Larry J. ; Lingappa, Jairam ; Widdowson, Marc Alain ; McLaughlin, J. ; Romney, M. ; Kimura, A. ; Dassey, D. ; Lash, B. ; Terashita, D. ; Klish, S. ; Cody, S. ; Farley, S. ; Lea, S. ; Sanderson, R. ; Wolthuis, J. ; Allard, C. ; Albanese, B. ; Nivin, B. ; McCall, P. ; Davies, M. ; Murphy, M. ; Koch, E. ; Weltman, A. ; Brumund, H. ; Barton, C. ; Whetstone, K. ; Bellini, W. J. ; Bialek, S. ; Comer, J. A. ; Emery, S. ; Helfand, R. ; Hennessy, T. ; James, A. ; LaMonte, A. ; Newbern, E. C. ; Scott, S. ; Simpson, L. ; Siwek, A. ; Smelser, C. ; Stockman, L. ; Lu, X. ; White, D. / SARS-associated Coronavirus Transmission, United States. In: Emerging infectious diseases. 2004 ; Vol. 10, No. 2. pp. 225-231.

@article{39ca14f3285b4595ba5106ff6a5b9f5a,

title = "SARS-associated Coronavirus Transmission, United States",

abstract = "To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.",

author = "Isakbaeva, {Elmira T.} and Nino Khetsuriani and Beard, {R. Suzanne} and Angela Peck and Dean Erdman and Monroe, {Stephan S.} and Suxiang Tong and Ksiazek, {Thomas G.} and Sara Lowther and Indra Pandya-Smith and Anderson, {Larry J.} and Jairam Lingappa and Widdowson, {Marc Alain} and J. McLaughlin and M. Romney and A. Kimura and D. Dassey and B. Lash and D. Terashita and S. Klish and S. Cody and S. Farley and S. Lea and R. Sanderson and J. Wolthuis and C. Allard and B. Albanese and B. Nivin and P. McCall and M. Davies and M. Murphy and E. Koch and A. Weltman and H. Brumund and C. Barton and K. Whetstone and Bellini, {W. J.} and S. Bialek and Comer, {J. A.} and S. Emery and R. Helfand and T. Hennessy and A. James and A. LaMonte and Newbern, {E. C.} and S. Scott and L. Simpson and A. Siwek and C. Smelser and L. Stockman and X. Lu and D. White",

year = "2004",

month = feb,

doi = "10.3201/eid1002.030734",

language = "English (US)",

volume = "10",

pages = "225--231",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "2",

}

TY - JOUR

T1 - SARS-associated Coronavirus Transmission, United States

AU - Isakbaeva, Elmira T.

AU - Khetsuriani, Nino

AU - Beard, R. Suzanne

AU - Peck, Angela

AU - Erdman, Dean

AU - Monroe, Stephan S.

AU - Tong, Suxiang

AU - Ksiazek, Thomas G.

AU - Lowther, Sara

AU - Pandya-Smith, Indra

AU - Anderson, Larry J.

AU - Lingappa, Jairam

AU - Widdowson, Marc Alain

AU - McLaughlin, J.

AU - Romney, M.

AU - Kimura, A.

AU - Dassey, D.

AU - Lash, B.

AU - Terashita, D.

AU - Klish, S.

AU - Cody, S.

AU - Farley, S.

AU - Lea, S.

AU - Sanderson, R.

AU - Wolthuis, J.

AU - Allard, C.

AU - Albanese, B.

AU - Nivin, B.

AU - McCall, P.

AU - Davies, M.

AU - Murphy, M.

AU - Koch, E.

AU - Weltman, A.

AU - Brumund, H.

AU - Barton, C.

AU - Whetstone, K.

AU - Bellini, W. J.

AU - Bialek, S.

AU - Comer, J. A.

AU - Emery, S.

AU - Helfand, R.

AU - Hennessy, T.

AU - James, A.

AU - LaMonte, A.

AU - Newbern, E. C.

AU - Scott, S.

AU - Simpson, L.

AU - Siwek, A.

AU - Smelser, C.

AU - Stockman, L.

AU - Lu, X.

AU - White, D.

PY - 2004/2

Y1 - 2004/2

N2 - To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.

AB - To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.

UR - http://www.scopus.com/inward/record.url?scp=10744224740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744224740&partnerID=8YFLogxK

U2 - 10.3201/eid1002.030734

DO - 10.3201/eid1002.030734

M3 - Article

C2 - 15030687

AN - SCOPUS:10744224740

VL - 10

SP - 225

EP - 231

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6040

IS - 2

ER -