SARS-Like coronavirus WIV1-CoV does not replicate in Egyptian fruit bats (Rousettus aegyptiacus)

Neeltje van Doremalen, Alexandra Schäfer, Vineet Menachery, Michael Letko, Trenton Bushmaker, Robert J. Fischer, Dania M. Figueroa, Patrick W. Hanley, Greg Saturday, Ralph S. Baric, Vincent J. Munster

Research output: Contribution to journalArticle


Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from Rhinolophus sinicus bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect Rousettus aegyptiacus bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in Rousettus aegyptiacus bats.

Original languageEnglish (US)
Article number727
Issue number12
StatePublished - Dec 1 2018
Externally publishedYes



  • Animal model
  • Coronavirus
  • Emerging infectious diseases
  • WIV1-CoV

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

van Doremalen, N., Schäfer, A., Menachery, V., Letko, M., Bushmaker, T., Fischer, R. J., Figueroa, D. M., Hanley, P. W., Saturday, G., Baric, R. S., & Munster, V. J. (2018). SARS-Like coronavirus WIV1-CoV does not replicate in Egyptian fruit bats (Rousettus aegyptiacus). Viruses, 10(12), [727].