SCHIP

Statistics for chromosome interphase positioning based on interchange data

Sergi Vives, Bradford Loucas, Mariel Vazquez, David J. Brenner, Rainer K. Sachs, Lynn Hlatky, Michael Cornforth, Javier Arsuaga

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Motivation: The position of chromosomes in the interphase nucleus is believed to be associated with a number of biological processes. Here, we present a web-based application that helps analyze the relative position of chromosomes during interphase in human cells, based on observed radiogenic chromosome aberrations. The inputs of the program are a table of yields of pairwise chromosome interchanges and a proposed chromosome geometric cluster. Each can either be uploaded or selected from provided datasets. The main outputs are P-values for the proposed chromosome clusters. SCHIP is designed to be used by a number of scientific communities interested in nuclear architecture, including cancer and cell biologists, radiation biologists and mathematical/computational biologists.

Original languageEnglish (US)
Pages (from-to)3181-3182
Number of pages2
JournalBioinformatics
Volume21
Issue number14
DOIs
StatePublished - Jul 15 2005

Fingerprint

Chromosome Positioning
Interphase
Interchanges
Chromosomes
Positioning
Chromosome
Statistics
Biological Phenomena
Chromosome Aberrations
Cell
Aberrations
Aberration
Web-based
Nucleus
Pairwise
Radiation
Table
Cancer
Cells
Output

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Computer Science Applications
  • Computational Theory and Mathematics

Cite this

Vives, S., Loucas, B., Vazquez, M., Brenner, D. J., Sachs, R. K., Hlatky, L., ... Arsuaga, J. (2005). SCHIP: Statistics for chromosome interphase positioning based on interchange data. Bioinformatics, 21(14), 3181-3182. https://doi.org/10.1093/bioinformatics/bti470

SCHIP : Statistics for chromosome interphase positioning based on interchange data. / Vives, Sergi; Loucas, Bradford; Vazquez, Mariel; Brenner, David J.; Sachs, Rainer K.; Hlatky, Lynn; Cornforth, Michael; Arsuaga, Javier.

In: Bioinformatics, Vol. 21, No. 14, 15.07.2005, p. 3181-3182.

Research output: Contribution to journalArticle

Vives, S, Loucas, B, Vazquez, M, Brenner, DJ, Sachs, RK, Hlatky, L, Cornforth, M & Arsuaga, J 2005, 'SCHIP: Statistics for chromosome interphase positioning based on interchange data', Bioinformatics, vol. 21, no. 14, pp. 3181-3182. https://doi.org/10.1093/bioinformatics/bti470
Vives, Sergi ; Loucas, Bradford ; Vazquez, Mariel ; Brenner, David J. ; Sachs, Rainer K. ; Hlatky, Lynn ; Cornforth, Michael ; Arsuaga, Javier. / SCHIP : Statistics for chromosome interphase positioning based on interchange data. In: Bioinformatics. 2005 ; Vol. 21, No. 14. pp. 3181-3182.
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