Scientific vs. statistical inference: the problem of multiple contrasts in clinical research.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The problem of type 1 error rates in clinical medicine research is discussed and a new measure of evaluating the incidences of type 1 error is presented. Three measures, including the experimentwise error rate, the error rate per experiment, and the percentage error rate are used to compute the type 1 error in a sample of clinical research. The results suggest the presence of a substantial incidence of type 1 error in the sampled research. The implications for statistical and scientific inferences are briefly discussed and some possible solutions explored.

Original languageEnglish (US)
Pages (from-to)172-177
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume295
Issue number3
StatePublished - Mar 1988
Externally publishedYes

Fingerprint

Research
Clinical Medicine
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{839959eb00694a6db2b11de6f3249306,
title = "Scientific vs. statistical inference: the problem of multiple contrasts in clinical research.",
abstract = "The problem of type 1 error rates in clinical medicine research is discussed and a new measure of evaluating the incidences of type 1 error is presented. Three measures, including the experimentwise error rate, the error rate per experiment, and the percentage error rate are used to compute the type 1 error in a sample of clinical research. The results suggest the presence of a substantial incidence of type 1 error in the sampled research. The implications for statistical and scientific inferences are briefly discussed and some possible solutions explored.",
author = "Kenneth Ottenbacher",
year = "1988",
month = "3",
language = "English (US)",
volume = "295",
pages = "172--177",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Scientific vs. statistical inference

T2 - the problem of multiple contrasts in clinical research.

AU - Ottenbacher, Kenneth

PY - 1988/3

Y1 - 1988/3

N2 - The problem of type 1 error rates in clinical medicine research is discussed and a new measure of evaluating the incidences of type 1 error is presented. Three measures, including the experimentwise error rate, the error rate per experiment, and the percentage error rate are used to compute the type 1 error in a sample of clinical research. The results suggest the presence of a substantial incidence of type 1 error in the sampled research. The implications for statistical and scientific inferences are briefly discussed and some possible solutions explored.

AB - The problem of type 1 error rates in clinical medicine research is discussed and a new measure of evaluating the incidences of type 1 error is presented. Three measures, including the experimentwise error rate, the error rate per experiment, and the percentage error rate are used to compute the type 1 error in a sample of clinical research. The results suggest the presence of a substantial incidence of type 1 error in the sampled research. The implications for statistical and scientific inferences are briefly discussed and some possible solutions explored.

UR - http://www.scopus.com/inward/record.url?scp=0023968265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023968265&partnerID=8YFLogxK

M3 - Article

C2 - 3354590

AN - SCOPUS:0023968265

VL - 295

SP - 172

EP - 177

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 3

ER -