Sclerosis therapy of bronchial artery attenuates acute lung injury induced by burn and smoke inhalation injury in ovine model

Atsumori Hamahata, Perenlei Enkhbaatar, Hiroyuki Sakurai, Motohiro Nozaki, Daniel L. Traber

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Introduction: In burned sheep, we showed more than a 10-fold increase in bronchial blood flow following smoke inhalation. It was previously reported that sclerosis of the bronchial artery prior to smoke exposure reduces the pathophysiology of the inhalation insult. We hypothesized that sclerosis of the bronchial artery after insult attenuates smoke/burn-induced acute lung injury. Methods: Through an incision at the 4th intercostal space, a catheter was placed via the esophageal artery into the bronchial artery such that the bronchial blood flow remained intact. Acute lung injury was induced by a 40% total body surface area, 3rd degree cutaneous burn and smoke inhalation. Adult female sheep (n = 18, 35.6 ± 1.0 kg) were divided into three groups following the injury: (1) sclerosis group: 1 h after injury, 4 mL of 70% ethanol was injected into bronchial artery via bronchial catheter, n = 6; (2) control group: 1 h after injury, an equal dose of saline was injected into bronchial artery via the bronchial catheter, n = 6; (3) sham group: no injury and no treatment, n = 6. The experiment was conducted in awake animals for 24 h. Results: Bronchial blood flow, measured by microspheres, was significantly reduced after ethanol injection in the sclerosis group. Pulmonary function, evaluated by measurement of blood gas analysis, pulmonary mechanics, and pulmonary transvascular fluid flux, was severely impaired in the control group. However, pulmonary function was significantly improved by bronchial artery sclerosis. Conclusion: The results of our study clearly demonstrate a crucial role of enhanced bronchial circulation in thermal injury-related morbidity. Decreasing bronchial circulation using pharmacological agents may be an effective strategy in management of burn patients with concomitant smoke inhalation injury.

Original languageEnglish (US)
Pages (from-to)1042-1049
Number of pages8
JournalBurns
Volume36
Issue number7
DOIs
StatePublished - Nov 2010

Fingerprint

Smoke Inhalation Injury
Bronchial Arteries
Acute Lung Injury
Sclerosis
Sheep
Smoke
Wounds and Injuries
Lung
Catheters
Inhalation
Inhalation Burns
Ethanol
Therapeutics
Control Groups
Blood Gas Analysis
Body Surface Area
Mechanics
Microspheres
Burns
Arteries

Keywords

  • Acute respiratory distress syndrome
  • Bronchial artery
  • Burn injury
  • Sclerosis
  • Smoke inhalation injury

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine
  • Surgery

Cite this

Sclerosis therapy of bronchial artery attenuates acute lung injury induced by burn and smoke inhalation injury in ovine model. / Hamahata, Atsumori; Enkhbaatar, Perenlei; Sakurai, Hiroyuki; Nozaki, Motohiro; Traber, Daniel L.

In: Burns, Vol. 36, No. 7, 11.2010, p. 1042-1049.

Research output: Contribution to journalArticle

Hamahata, Atsumori ; Enkhbaatar, Perenlei ; Sakurai, Hiroyuki ; Nozaki, Motohiro ; Traber, Daniel L. / Sclerosis therapy of bronchial artery attenuates acute lung injury induced by burn and smoke inhalation injury in ovine model. In: Burns. 2010 ; Vol. 36, No. 7. pp. 1042-1049.
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AB - Introduction: In burned sheep, we showed more than a 10-fold increase in bronchial blood flow following smoke inhalation. It was previously reported that sclerosis of the bronchial artery prior to smoke exposure reduces the pathophysiology of the inhalation insult. We hypothesized that sclerosis of the bronchial artery after insult attenuates smoke/burn-induced acute lung injury. Methods: Through an incision at the 4th intercostal space, a catheter was placed via the esophageal artery into the bronchial artery such that the bronchial blood flow remained intact. Acute lung injury was induced by a 40% total body surface area, 3rd degree cutaneous burn and smoke inhalation. Adult female sheep (n = 18, 35.6 ± 1.0 kg) were divided into three groups following the injury: (1) sclerosis group: 1 h after injury, 4 mL of 70% ethanol was injected into bronchial artery via bronchial catheter, n = 6; (2) control group: 1 h after injury, an equal dose of saline was injected into bronchial artery via the bronchial catheter, n = 6; (3) sham group: no injury and no treatment, n = 6. The experiment was conducted in awake animals for 24 h. Results: Bronchial blood flow, measured by microspheres, was significantly reduced after ethanol injection in the sclerosis group. Pulmonary function, evaluated by measurement of blood gas analysis, pulmonary mechanics, and pulmonary transvascular fluid flux, was severely impaired in the control group. However, pulmonary function was significantly improved by bronchial artery sclerosis. Conclusion: The results of our study clearly demonstrate a crucial role of enhanced bronchial circulation in thermal injury-related morbidity. Decreasing bronchial circulation using pharmacological agents may be an effective strategy in management of burn patients with concomitant smoke inhalation injury.

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