Scrub typhus in previously unrecognized areas of endemicity in China

Shouyin Zhang, Hongbin Song, Yan Liu, Qun Li, Yong Wang, Jiabin Wu, Junfeng Wan, Guolan Li, Changjun Yu, Xiuyong Li, Wenwu Yin, Zhen Xu, Bo Liu, Qian Zhang, Kanglin Wan, Guichang Li, Xiuping Fu, Jingshan Zhang, Jinrong He, Rong Hai & 4 others Dongzheng Yu, David Walker, Jianguo Xu, Xue Jie Yu

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Scrub typhus, caused by Orientia tsutsugamushi, has emerged recently in areas of northern China where the disease had not been known to exist. We analyzed epidemiological, clinical, and laboratory data for 104 patients who were admitted to a hospital in Fuyang City between 26 September and 1 November 2008. We showed that the major clinical manifestations of the patients were fever (100%), headache (82%), myalgias (77%), eschar (67%), rash (52%), and unusual facial flushing (62%). Among the 104 patients, the sera of 98% contained IgM antibodies to O. tsutsugamushi detected by indirect immunofluorescence assays (IFA), and DNA of the O. tsutsugamushi 56-kDa gene was amplified by PCR from the blood of 36 patients. We conclude that 104 patients were infected with scrub typhus in Fuyang City, Anhui Province. Our study indicates that physicians need to consider the diagnosis of scrub typhus for febrile patients living in northern China, where scrub typhus had not been considered to exist in the past.

Original languageEnglish (US)
Pages (from-to)1241-1244
Number of pages4
JournalJournal of Clinical Microbiology
Volume48
Issue number4
DOIs
StatePublished - Apr 1 2010

Fingerprint

Scrub Typhus
China
Orientia tsutsugamushi
Fever
Myalgia
Indirect Fluorescent Antibody Technique
Exanthema
Immunoglobulin M
Headache
Physicians
Polymerase Chain Reaction
Antibodies
DNA
Serum
Genes

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Zhang, S., Song, H., Liu, Y., Li, Q., Wang, Y., Wu, J., ... Yu, X. J. (2010). Scrub typhus in previously unrecognized areas of endemicity in China. Journal of Clinical Microbiology, 48(4), 1241-1244. https://doi.org/10.1128/JCM.01784-09

Scrub typhus in previously unrecognized areas of endemicity in China. / Zhang, Shouyin; Song, Hongbin; Liu, Yan; Li, Qun; Wang, Yong; Wu, Jiabin; Wan, Junfeng; Li, Guolan; Yu, Changjun; Li, Xiuyong; Yin, Wenwu; Xu, Zhen; Liu, Bo; Zhang, Qian; Wan, Kanglin; Li, Guichang; Fu, Xiuping; Zhang, Jingshan; He, Jinrong; Hai, Rong; Yu, Dongzheng; Walker, David; Xu, Jianguo; Yu, Xue Jie.

In: Journal of Clinical Microbiology, Vol. 48, No. 4, 01.04.2010, p. 1241-1244.

Research output: Contribution to journalArticle

Zhang, S, Song, H, Liu, Y, Li, Q, Wang, Y, Wu, J, Wan, J, Li, G, Yu, C, Li, X, Yin, W, Xu, Z, Liu, B, Zhang, Q, Wan, K, Li, G, Fu, X, Zhang, J, He, J, Hai, R, Yu, D, Walker, D, Xu, J & Yu, XJ 2010, 'Scrub typhus in previously unrecognized areas of endemicity in China', Journal of Clinical Microbiology, vol. 48, no. 4, pp. 1241-1244. https://doi.org/10.1128/JCM.01784-09
Zhang, Shouyin ; Song, Hongbin ; Liu, Yan ; Li, Qun ; Wang, Yong ; Wu, Jiabin ; Wan, Junfeng ; Li, Guolan ; Yu, Changjun ; Li, Xiuyong ; Yin, Wenwu ; Xu, Zhen ; Liu, Bo ; Zhang, Qian ; Wan, Kanglin ; Li, Guichang ; Fu, Xiuping ; Zhang, Jingshan ; He, Jinrong ; Hai, Rong ; Yu, Dongzheng ; Walker, David ; Xu, Jianguo ; Yu, Xue Jie. / Scrub typhus in previously unrecognized areas of endemicity in China. In: Journal of Clinical Microbiology. 2010 ; Vol. 48, No. 4. pp. 1241-1244.
@article{8b590a84c1ea4b628589c59d9dc74edd,
title = "Scrub typhus in previously unrecognized areas of endemicity in China",
abstract = "Scrub typhus, caused by Orientia tsutsugamushi, has emerged recently in areas of northern China where the disease had not been known to exist. We analyzed epidemiological, clinical, and laboratory data for 104 patients who were admitted to a hospital in Fuyang City between 26 September and 1 November 2008. We showed that the major clinical manifestations of the patients were fever (100{\%}), headache (82{\%}), myalgias (77{\%}), eschar (67{\%}), rash (52{\%}), and unusual facial flushing (62{\%}). Among the 104 patients, the sera of 98{\%} contained IgM antibodies to O. tsutsugamushi detected by indirect immunofluorescence assays (IFA), and DNA of the O. tsutsugamushi 56-kDa gene was amplified by PCR from the blood of 36 patients. We conclude that 104 patients were infected with scrub typhus in Fuyang City, Anhui Province. Our study indicates that physicians need to consider the diagnosis of scrub typhus for febrile patients living in northern China, where scrub typhus had not been considered to exist in the past.",
author = "Shouyin Zhang and Hongbin Song and Yan Liu and Qun Li and Yong Wang and Jiabin Wu and Junfeng Wan and Guolan Li and Changjun Yu and Xiuyong Li and Wenwu Yin and Zhen Xu and Bo Liu and Qian Zhang and Kanglin Wan and Guichang Li and Xiuping Fu and Jingshan Zhang and Jinrong He and Rong Hai and Dongzheng Yu and David Walker and Jianguo Xu and Yu, {Xue Jie}",
year = "2010",
month = "4",
day = "1",
doi = "10.1128/JCM.01784-09",
language = "English (US)",
volume = "48",
pages = "1241--1244",
journal = "Journal of Clinical Microbiology",
issn = "0095-1137",
publisher = "American Society for Microbiology",
number = "4",

}

TY - JOUR

T1 - Scrub typhus in previously unrecognized areas of endemicity in China

AU - Zhang, Shouyin

AU - Song, Hongbin

AU - Liu, Yan

AU - Li, Qun

AU - Wang, Yong

AU - Wu, Jiabin

AU - Wan, Junfeng

AU - Li, Guolan

AU - Yu, Changjun

AU - Li, Xiuyong

AU - Yin, Wenwu

AU - Xu, Zhen

AU - Liu, Bo

AU - Zhang, Qian

AU - Wan, Kanglin

AU - Li, Guichang

AU - Fu, Xiuping

AU - Zhang, Jingshan

AU - He, Jinrong

AU - Hai, Rong

AU - Yu, Dongzheng

AU - Walker, David

AU - Xu, Jianguo

AU - Yu, Xue Jie

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Scrub typhus, caused by Orientia tsutsugamushi, has emerged recently in areas of northern China where the disease had not been known to exist. We analyzed epidemiological, clinical, and laboratory data for 104 patients who were admitted to a hospital in Fuyang City between 26 September and 1 November 2008. We showed that the major clinical manifestations of the patients were fever (100%), headache (82%), myalgias (77%), eschar (67%), rash (52%), and unusual facial flushing (62%). Among the 104 patients, the sera of 98% contained IgM antibodies to O. tsutsugamushi detected by indirect immunofluorescence assays (IFA), and DNA of the O. tsutsugamushi 56-kDa gene was amplified by PCR from the blood of 36 patients. We conclude that 104 patients were infected with scrub typhus in Fuyang City, Anhui Province. Our study indicates that physicians need to consider the diagnosis of scrub typhus for febrile patients living in northern China, where scrub typhus had not been considered to exist in the past.

AB - Scrub typhus, caused by Orientia tsutsugamushi, has emerged recently in areas of northern China where the disease had not been known to exist. We analyzed epidemiological, clinical, and laboratory data for 104 patients who were admitted to a hospital in Fuyang City between 26 September and 1 November 2008. We showed that the major clinical manifestations of the patients were fever (100%), headache (82%), myalgias (77%), eschar (67%), rash (52%), and unusual facial flushing (62%). Among the 104 patients, the sera of 98% contained IgM antibodies to O. tsutsugamushi detected by indirect immunofluorescence assays (IFA), and DNA of the O. tsutsugamushi 56-kDa gene was amplified by PCR from the blood of 36 patients. We conclude that 104 patients were infected with scrub typhus in Fuyang City, Anhui Province. Our study indicates that physicians need to consider the diagnosis of scrub typhus for febrile patients living in northern China, where scrub typhus had not been considered to exist in the past.

UR - http://www.scopus.com/inward/record.url?scp=77950482012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950482012&partnerID=8YFLogxK

U2 - 10.1128/JCM.01784-09

DO - 10.1128/JCM.01784-09

M3 - Article

VL - 48

SP - 1241

EP - 1244

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 4

ER -