SDAP

Database and computational tools for allergenic proteins

Ovidiu Ivanciuc, Catherine H. Schein, Werner Braun

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

SDAP (Structural Database of Allergenic Proteins) is a web server that provides rapid, cross-referenced access to the sequences, structures and IgE epitopes of allergenic proteins. The SDAP core is a series of CGI scripts that process the user queries, interrogate the database, perform various computations related to protein allergenic determinants and prepare the output HTML pages. The database component of SDAP contains information about the allergen name, source, sequence, structure, IgE epitopes and literature references and easy links to the major protein (PDB, SWISS-PROT/TrEMBL, PIR-ALN, NCBI Taxonomy Browser) and literature (PubMed, MEDLINE) on-line servers. The computational component in SDAP uses an original algorithm based on conserved properties of amino acid side chains to identify regions of known allergens similar to user-supplied peptides or selected from the SDAP data-base of IgE epitopes. This and other bioinformatics tools can be used to rapidly determine potential cross-reactivities between allergens and to screen novel proteins for the presence of IgE epitopes they may share with known allergens. SDAP is available via the World Wide Web at http://fermi.utmb.edu/SDAP.

Original languageEnglish
Pages (from-to)359-362
Number of pages4
JournalNucleic Acids Research
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2003

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Protein Databases
Databases
Allergens
Immunoglobulin E
Epitopes
Proteins
Computational Biology
PubMed
MEDLINE
Internet
Names
Amino Acids
Peptides

ASJC Scopus subject areas

  • Genetics

Cite this

SDAP : Database and computational tools for allergenic proteins. / Ivanciuc, Ovidiu; Schein, Catherine H.; Braun, Werner.

In: Nucleic Acids Research, Vol. 31, No. 1, 01.01.2003, p. 359-362.

Research output: Contribution to journalArticle

Ivanciuc, Ovidiu ; Schein, Catherine H. ; Braun, Werner. / SDAP : Database and computational tools for allergenic proteins. In: Nucleic Acids Research. 2003 ; Vol. 31, No. 1. pp. 359-362.
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