Search for the Ebola virus reservoir in Kikwit, Democratic Republic of the Congo: Reflections on a vertebrate collection

Herwig Leirs, James N. Mills, John W. Krebs, James E. Childs, Dudu Akaibe, Neal Woollen, George Ludwig, Clarence J. Peters, Thomas Ksiazek

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

A 3-month ecologic investigation was done to identify the reservoir of Ebola virus following the 1995 outbreak in Kikwit, Democratic Republic of the Congo. Efforts focused on the fields where the putative primary case had worked but included other habitats near Kikwit. Samples were collected from 3066 vertebrates and tested for the presence of antibodies to Ebola (subtype Zaire) virus: All tests were negative, and attempts to isolate Ebola virus were unsuccessful. The investigation was hampered by a lack of information beyond the daily activities of the primary case, a lack of information on Ebola virus ecology, which precluded the detailed study of select groups of animals, and sample-size limitations for rare species. The epidemiology of Ebola hemorrhagic fever suggests that humans have only intermittent contact with the virus, which complicates selection of target species. Further study of the epidemiology of human outbreaks to further define the environmental contact of primary cases would be of great value.

Original languageEnglish (US)
JournalJournal of Infectious Diseases
Volume179
Issue numberSUPPL. 1
StatePublished - 1999
Externally publishedYes

Fingerprint

Ebolavirus
Democratic Republic of the Congo
Vertebrates
Disease Outbreaks
Ebola Hemorrhagic Fever
Epidemiology
Ecology
Sample Size
Ecosystem
Viruses
Antibodies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Search for the Ebola virus reservoir in Kikwit, Democratic Republic of the Congo : Reflections on a vertebrate collection. / Leirs, Herwig; Mills, James N.; Krebs, John W.; Childs, James E.; Akaibe, Dudu; Woollen, Neal; Ludwig, George; Peters, Clarence J.; Ksiazek, Thomas.

In: Journal of Infectious Diseases, Vol. 179, No. SUPPL. 1, 1999.

Research output: Contribution to journalArticle

Leirs, H, Mills, JN, Krebs, JW, Childs, JE, Akaibe, D, Woollen, N, Ludwig, G, Peters, CJ & Ksiazek, T 1999, 'Search for the Ebola virus reservoir in Kikwit, Democratic Republic of the Congo: Reflections on a vertebrate collection', Journal of Infectious Diseases, vol. 179, no. SUPPL. 1.
Leirs, Herwig ; Mills, James N. ; Krebs, John W. ; Childs, James E. ; Akaibe, Dudu ; Woollen, Neal ; Ludwig, George ; Peters, Clarence J. ; Ksiazek, Thomas. / Search for the Ebola virus reservoir in Kikwit, Democratic Republic of the Congo : Reflections on a vertebrate collection. In: Journal of Infectious Diseases. 1999 ; Vol. 179, No. SUPPL. 1.
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