Searching for immune correlates in Lassa vaccine development – workshop report

Trevor Brasel; Polina Brangel; Ifedayo Adetifa; Sylvain Baize; David Benkeser; Antonio Bertoletti; Alexander Bukreyev; Sue Charlton; Jakob Cramer; Robert W. Cross; Miles P. Davenport; Devy Emperador; Pierre Formenty; Dean Follmann; Robert F. Garry; Peter B. Gilbert; Sarah C. Gilbert; Jimmy D. Gollihar; Nicholas C. Grassly; Marion Gruber; Swati B. Gupta; Stephan Günther; Adam Hacker; Catherine Hoath; Michael R. Holbrook; Marian Killip; Deborah King; Henshaw Mandi; Vincent J. Munster; Christinah Mukandavire; Lisa Oestereich; Sylvanus Okogbenin; Paul Oloo; Slobodan Paessler; Stanley Plotkin; Laura Richert; David Safronetz; Erica Ollmann Saphire; Alessandro Sette; Amy Shurtleff; Julia Granerod; David Wohl; Marija Zaric; Katrin Ramsauer; Christine Dahlke

doi:10.1038/s41541-026-01452-6

Searching for immune correlates in Lassa vaccine development – workshop report

Trevor Brasel
, Polina Brangel
, Ifedayo Adetifa
, Sylvain Baize
, David Benkeser
, Antonio Bertoletti
, Alexander Bukreyev
, Sue Charlton
, Jakob Cramer
, Robert W. Cross
, Miles P. Davenport
, Devy Emperador
, Pierre Formenty
, Dean Follmann
, Robert F. Garry
, Peter B. Gilbert
, Sarah C. Gilbert
, Jimmy D. Gollihar
, Nicholas C. Grassly
, Marion Gruber

Swati B. Gupta, Stephan Günther, Adam Hacker, Catherine Hoath, Michael R. Holbrook, Marian Killip, Deborah King, Henshaw Mandi, Vincent J. Munster, Christinah Mukandavire, Lisa Oestereich, Sylvanus Okogbenin, Paul Oloo, Slobodan Paessler, Stanley Plotkin, Laura Richert, David Safronetz, Erica Ollmann Saphire, Alessandro Sette, Amy Shurtleff, Julia Granerod, David Wohl, Marija Zaric, Katrin Ramsauer, Christine Dahlke

Research output: Contribution to journal › Article › peer-review

Abstract

The first workshop dedicated to Lassa virus–specific correlates of protection (CoP) was held in 2024 and was convened by the Coalition for Epidemic Preparedness Innovations (CEPI). Experts from multiple disciplines reviewed existing knowledge and identified gaps in understanding Lassa virus- and vaccine-induced immune responses. Discussions covered key areas including epidemiology, immunogenicity, preclinical and clinical research, data science, and regulatory considerations, with the goal of pinpointing opportunities to discover CoP.

Original language	English (US)
Article number	95
Journal	npj Vaccines
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41541-026-01452-6
State	Published - Dec 2026

ASJC Scopus subject areas

Immunology
Pharmacology
Infectious Diseases
Pharmacology (medical)

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Brasel, T., Brangel, P., Adetifa, I., Baize, S., Benkeser, D., Bertoletti, A., Bukreyev, A., Charlton, S., Cramer, J., Cross, R. W., Davenport, M. P., Emperador, D., Formenty, P., Follmann, D., Garry, R. F., Gilbert, P. B., Gilbert, S. C., Gollihar, J. D., Grassly, N. C., ... Dahlke, C. (2026). Searching for immune correlates in Lassa vaccine development – workshop report. npj Vaccines, 11(1), Article 95. https://doi.org/10.1038/s41541-026-01452-6

Brasel, T, Brangel, P, Adetifa, I, Baize, S, Benkeser, D, Bertoletti, A, Bukreyev, A, Charlton, S, Cramer, J, Cross, RW, Davenport, MP, Emperador, D, Formenty, P, Follmann, D, Garry, RF, Gilbert, PB, Gilbert, SC, Gollihar, JD, Grassly, NC, Gruber, M, Gupta, SB, Günther, S, Hacker, A, Hoath, C, Holbrook, MR, Killip, M, King, D, Mandi, H, Munster, VJ, Mukandavire, C, Oestereich, L, Okogbenin, S, Oloo, P, Paessler, S, Plotkin, S, Richert, L, Safronetz, D, Saphire, EO, Sette, A, Shurtleff, A, Granerod, J, Wohl, D, Zaric, M, Ramsauer, K & Dahlke, C 2026, 'Searching for immune correlates in Lassa vaccine development – workshop report', npj Vaccines, vol. 11, no. 1, 95. https://doi.org/10.1038/s41541-026-01452-6

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title = "Searching for immune correlates in Lassa vaccine development – workshop report",

abstract = "The first workshop dedicated to Lassa virus–specific correlates of protection (CoP) was held in 2024 and was convened by the Coalition for Epidemic Preparedness Innovations (CEPI). Experts from multiple disciplines reviewed existing knowledge and identified gaps in understanding Lassa virus- and vaccine-induced immune responses. Discussions covered key areas including epidemiology, immunogenicity, preclinical and clinical research, data science, and regulatory considerations, with the goal of pinpointing opportunities to discover CoP.",

author = "Trevor Brasel and Polina Brangel and Ifedayo Adetifa and Sylvain Baize and David Benkeser and Antonio Bertoletti and Alexander Bukreyev and Sue Charlton and Jakob Cramer and Cross, \{Robert W.\} and Davenport, \{Miles P.\} and Devy Emperador and Pierre Formenty and Dean Follmann and Garry, \{Robert F.\} and Gilbert, \{Peter B.\} and Gilbert, \{Sarah C.\} and Gollihar, \{Jimmy D.\} and Grassly, \{Nicholas C.\} and Marion Gruber and Gupta, \{Swati B.\} and Stephan G{\"u}nther and Adam Hacker and Catherine Hoath and Holbrook, \{Michael R.\} and Marian Killip and Deborah King and Henshaw Mandi and Munster, \{Vincent J.\} and Christinah Mukandavire and Lisa Oestereich and Sylvanus Okogbenin and Paul Oloo and Slobodan Paessler and Stanley Plotkin and Laura Richert and David Safronetz and Saphire, \{Erica Ollmann\} and Alessandro Sette and Amy Shurtleff and Julia Granerod and David Wohl and Marija Zaric and Katrin Ramsauer and Christine Dahlke",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2026.",

year = "2026",

month = dec,

doi = "10.1038/s41541-026-01452-6",

language = "English (US)",

volume = "11",

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AU - Brasel, Trevor

AU - Brangel, Polina

AU - Adetifa, Ifedayo

AU - Baize, Sylvain

AU - Benkeser, David

AU - Bertoletti, Antonio

AU - Bukreyev, Alexander

AU - Charlton, Sue

AU - Cramer, Jakob

AU - Cross, Robert W.

AU - Davenport, Miles P.

AU - Emperador, Devy

AU - Formenty, Pierre

AU - Follmann, Dean

AU - Garry, Robert F.

AU - Gilbert, Peter B.

AU - Gilbert, Sarah C.

AU - Gollihar, Jimmy D.

AU - Grassly, Nicholas C.

AU - Gruber, Marion

AU - Gupta, Swati B.

AU - Günther, Stephan

AU - Hacker, Adam

AU - Hoath, Catherine

AU - Holbrook, Michael R.

AU - Killip, Marian

AU - King, Deborah

AU - Mandi, Henshaw

AU - Munster, Vincent J.

AU - Mukandavire, Christinah

AU - Oestereich, Lisa

AU - Okogbenin, Sylvanus

AU - Oloo, Paul

AU - Paessler, Slobodan

AU - Plotkin, Stanley

AU - Richert, Laura

AU - Safronetz, David

AU - Saphire, Erica Ollmann

AU - Sette, Alessandro

AU - Shurtleff, Amy

AU - Granerod, Julia

AU - Wohl, David

AU - Zaric, Marija

AU - Ramsauer, Katrin

AU - Dahlke, Christine

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Searching for immune correlates in Lassa vaccine development – workshop report

Abstract

ASJC Scopus subject areas

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