Secretory IgA in the serum of infants with obstructive jaundice

Randall Mark Goldblum, Geraldine Keating Powell, Greggory Van Sickle

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The liver is capable of transporting IgA from the plasma to bile in several experimental animals. After bile duct ligation, SIgA and free secretory component accumulate in the serum of these animals. In the present study, SIgA was found in the serum of all infants with extrahepatic biliary obstruction, and in 75% of those with intrahepatic cholestasis, but in only one of seven age-matched infants without hepatobiliary disease. Infants with EHBO had significantly higher serum levels of secretory IgA and total IgA than in normal infants or patients with IHC. This result suggests that the human liver is involved in SIgA metabolism and that the elevated serum IgA levels in infants with liver disease are caused by bile duct obstruction or proliferation. Quantitation of SIgA in serum may help to differentiate major categories of obstructive jaundice in infancy. The concentration of SIgA in serum was indicative of the site of obstruction in 12 of 19 infants with hepatobiliary disease.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalThe Journal of pediatrics
Volume97
Issue number1
DOIs
StatePublished - 1980

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Secretory Immunoglobulin A
Obstructive Jaundice
Serum
Immunoglobulin A
Secretory Component
Intrahepatic Cholestasis
Liver
Cholestasis
Bile Ducts
Bile
Ligation
Liver Diseases

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Secretory IgA in the serum of infants with obstructive jaundice. / Goldblum, Randall Mark; Powell, Geraldine Keating; Sickle, Greggory Van.

In: The Journal of pediatrics, Vol. 97, No. 1, 1980, p. 33-36.

Research output: Contribution to journalArticle

Goldblum, Randall Mark ; Powell, Geraldine Keating ; Sickle, Greggory Van. / Secretory IgA in the serum of infants with obstructive jaundice. In: The Journal of pediatrics. 1980 ; Vol. 97, No. 1. pp. 33-36.
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