Security and efficiency of a closed-system, turbulent-flow circuit for hyperthermic intraperitoneal chemotherapy after cytoreductive ovarian surgery: Perioperative outputs

Francisco Pascual-Ramirez, Susana Sánchez García, Francisco González Ruiz De La Herrán, Pedro Villarejo Campos, Carlos López De La Manzanara Cano, Javier Haya Palazuelo, David Padilla Valverde, Jesús Martín Fernández

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Objective: To present physiologic intraoperative data and immediate postoperative outcomes of patients diagnosed with epithelial ovarian cancer submitted to cytoreductive surgery and hyperthermic peritoneal intraoperative chemotherapy (HIPEC) with a closed-circuit, turbulent-flow system. Materials and methods: A closed-circuit system with CO2 turbulent flow was used for paclitaxel HIPEC during 60 min for patients diagnosed with stage II or higher and recurrent epithelial ovarian cancer. Perioperative hemodynamic and metabolic statuses were followed, as well as physiologic recovery during the first 12 postoperative hours. A non-parametric statistical analysis was performed. Results: At the end of the hyperthermia phase, temperature was 37.7 ± 0.6 °C, heart rate 88 ± 19 bpm, cardiac index 2.8 ± 0.5 L min-1 m-2, stroke volume variation 14.6 ± 3.6 % and extravascular lung water 8.7 ± 1.9 mL kg-1. No hyperdynamic status was recorded. The length of stay in the ICU was 21/2 days, and 12.7 ± 7 days in hospital. Average postoperative intubation time was 11.7 ± 17.4 h. At the ICU admission time, glucose, lactic acid and hemoglobin were the only values out of range, but close to normal. SOFA median was 3 at admission and 0 the following day. Conclusion: A turbulent-flow, closed-circuit use for hyperthermic peritoneal intraoperative chemotherapy resulted in no hyperdynamic response or coagulopathy, had good tolerance and promoted early physiologic recovery.

Original languageEnglish (US)
Pages (from-to)121-129
Number of pages9
JournalArchives of Gynecology and Obstetrics
Volume290
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Keywords

  • Epithelial ovarian cancer
  • Hyperthermic intraperitoneal chemotherapy
  • Intraoperative outputs
  • Postoperative outcomes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Pascual-Ramirez, F., Sánchez García, S., González Ruiz De La Herrán, F., Villarejo Campos, P., López De La Manzanara Cano, C., Haya Palazuelo, J., Padilla Valverde, D., & Martín Fernández, J. (2014). Security and efficiency of a closed-system, turbulent-flow circuit for hyperthermic intraperitoneal chemotherapy after cytoreductive ovarian surgery: Perioperative outputs. Archives of Gynecology and Obstetrics, 290(1), 121-129. https://doi.org/10.1007/s00404-014-3153-4