Segmental spinal nerve ligation model of neuropathic pain.

Jin Chung, Hee Kee Kim, Kyungsoon Chung

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Since its introduction in 1992, the spinal nerve ligation (SNL) model of neuropathic pain has been widely used for various investigative works on neuropathic pain mechanisms as well as in screening tests for the development of new analgesic drugs. This model was developed by tightly ligating one (L5) or two (L5 and L6) segmental spinal nerves in the rat. The operation results in long-lasting behavioral signs of mechanical allodynia, heat hyperalgesia, cold allodynia, and ongoing pain. In the process of widespread usage, however, many different variations of the SNL model have been produced, either intentionally or unintentionally, by different investigators. Although the factors that cause these variations themselves are interesting and important topics to be studied, the pain mechanisms involved in these variations are likely different from the original model. Therefore, this chapter describes, in detail, the method for producing the spinal nerve ligation model that will minimally induce potential factors that may contribute to these variations. It is hoped that this description will help many investigators to produce a consistent animal model with uniform pathophysiological mechanisms.

Original languageEnglish (US)
Pages (from-to)35-45
Number of pages11
JournalMethods in molecular medicine
Volume99
StatePublished - 2004

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Spinal Nerves
Neuralgia
Ligation
Hyperalgesia
Research Personnel
Pain
Analgesics
Animal Models
Hot Temperature

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Segmental spinal nerve ligation model of neuropathic pain. / Chung, Jin; Kim, Hee Kee; Chung, Kyungsoon.

In: Methods in molecular medicine, Vol. 99, 2004, p. 35-45.

Research output: Contribution to journalArticle

Chung, Jin ; Kim, Hee Kee ; Chung, Kyungsoon. / Segmental spinal nerve ligation model of neuropathic pain. In: Methods in molecular medicine. 2004 ; Vol. 99. pp. 35-45.
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