TY - JOUR
T1 - Selection of Phlebotomus papatasi (diptera
T2 - psychodidae) lines susceptible and refractory to Leishmania major infection
AU - Wu, W. K.
AU - Tesh, R. B.
PY - 1990
Y1 - 1990
N2 - Variation in susceptibility to infection with cultured promastigotes of Leishmania major was detected among 3 different geographic strains (ISRAEL, EGYPT, and INDIA) of the sand fly Phlebotomus papatasi. The ISRAEL strain showed the greatest susceptibility and was chosen for subsequent genetic selection experiments. After 13 generations of genetic selection in this strain, a stable refractory line was obtained in which only 7.5% of the insects could be infected. A highly susceptible line was also obtained in 5 generations of selection. Infection rates in the susceptible line were stabilized at about 94%. A description of the selection process and characteristics of the 2 lines are given.
AB - Variation in susceptibility to infection with cultured promastigotes of Leishmania major was detected among 3 different geographic strains (ISRAEL, EGYPT, and INDIA) of the sand fly Phlebotomus papatasi. The ISRAEL strain showed the greatest susceptibility and was chosen for subsequent genetic selection experiments. After 13 generations of genetic selection in this strain, a stable refractory line was obtained in which only 7.5% of the insects could be infected. A highly susceptible line was also obtained in 5 generations of selection. Infection rates in the susceptible line were stabilized at about 94%. A description of the selection process and characteristics of the 2 lines are given.
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U2 - 10.4269/ajtmh.1990.42.320
DO - 10.4269/ajtmh.1990.42.320
M3 - Article
C2 - 2331041
AN - SCOPUS:0025236750
SN - 0002-9637
VL - 42
SP - 320
EP - 328
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 4
ER -