Selection of thioaptamers for diagnostics and therapeutics

Xianbin Yang, He Wang, David W.C. Beasley, David E. Volk, Xu Zhao, Bruce A. Luxon, Lee O. Lomas, Norbert K. Herzog, Judith F. Aronson, Alan D.T. Barrett, James F. Leary, David G. Gorenstein

Research output: Chapter in Book/Report/Conference proceedingConference contribution

23 Scopus citations

Abstract

Thioaptamers offer advantages over normal phosphate ester backbone aptamers due to their enhanced affinity, specificity, and higher stability, largely due to the properties of the sulfur backbone modifications. Over the past several years, in vitro thioaptamer selection and bead-based thioaptamer selection techniques have been developed in our laboratory. Furthermore, several thioaptamers targeting specific proteins such as transcription factor NF-κ and AP-1 proteins have been identified. Selected thioaptamers have been shown diagnostic promise in proteome screens. Moreover, some promising thioaptamers have been shown in preliminary animal therapeutic dosing to increase survival in animal models of infection with West Nile virus.

Original languageEnglish (US)
Title of host publicationOligonucleotide Therapeutics
Subtitle of host publicationFirst Annual Meeting of the Oligonucleotide Therapeutics Society
PublisherBlackwell Publishing Inc.
Pages116-119
Number of pages4
ISBN (Print)1573315877, 9781573315876
DOIs
StatePublished - Oct 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1082
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Antiviral agent
  • Aptamer
  • Diagnostics
  • Oligonucleotide phosphorodithioate
  • Oligonucleotide phosphorothioate
  • Therapeutics
  • Thioaptamer

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Yang, X., Wang, H., Beasley, D. W. C., Volk, D. E., Zhao, X., Luxon, B. A., Lomas, L. O., Herzog, N. K., Aronson, J. F., Barrett, A. D. T., Leary, J. F., & Gorenstein, D. G. (2006). Selection of thioaptamers for diagnostics and therapeutics. In Oligonucleotide Therapeutics: First Annual Meeting of the Oligonucleotide Therapeutics Society (pp. 116-119). (Annals of the New York Academy of Sciences; Vol. 1082). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1348.065