Selective induction of c-Jun and NGF in reactive astrocytes after cholinergic degenerations in rat basal forebrain

Steffen Roßner, Reinhard Schliebs, Wolfgang Härtig, J. Regino Perez-Polo, Volker Bigl

    Research output: Contribution to journalArticle

    32 Scopus citations

    Abstract

    Cholinergic basal forebrain neurons are the major source of cortical cholinergic innervation. The number of these neurons is regulated by the availability of nerve growth factor (NGF) during development while in adulthood their cholinergic activity is modulated by NGF. In previous studies we have shown that cholinergic immunolesions of basal forebrain neurons increase local immediate early gene expression and NGF synthesis in the regions of degeneration. In this study we identify the cellular source of c- Jun and NGF expression using dual immunolabeling of c-Jun and NGF in combination with neuronal and glial markers. We demonstrate that both c-Jun and NGF are exclusively expressed in reactive astrocytes but not in microglia or in GABAergic basal forebrain neurons. These observations support the hypothesis that reactive astrocytes synthesize neurotrophic substances in vivo in response to neuronal degeneration in the basal forebrain.

    Original languageEnglish (US)
    Pages (from-to)2199-2202
    Number of pages4
    JournalNeuroReport
    Volume8
    Issue number9-10
    DOIs
    StatePublished - 1997

    Keywords

    • 192IgG-saporin
    • Glia
    • Immediate early genes
    • Immunolesion
    • Nerve growth factor
    • Neurotrophins
    • Regeneration

    ASJC Scopus subject areas

    • Neuroscience(all)

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