Selective pancreatic toxicity of palmitoylpentachlorophenol

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Palmitoylpentachlorophenol (PPCP), which is a lipid conjugate of a xenobiotic compound, has been found in human fat. To study the toxicity associated with PPCP, rats were given 100 mg/kg PPCP and sacrificed at 4, 8 and 12 days. The target organ identified was the exocrine pancreas; no other major organs examined showed any gross or histopathological abnormality. At 4 and 8 days after treatment, focal, spotty vacuolation, and loss of pancreatic acini was observed. Acute inflammatory infiltrate was also observed in parenchyma at all time points and the loss of acinar tissue was resolved through fibrous tissue formation by 12 days. The present study indicates that PPCP has a specific target organ toxicity.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalToxicology
Volume46
Issue number1
DOIs
StatePublished - Oct 12 1987

Fingerprint

Toxicity
Tissue
Exocrine Pancreas
Xenobiotics
Rats
Fats
Lipids
pentachlorophenyl palmitate

Keywords

  • fatty acid conjugate
  • Palmitoylpentachlorophenol
  • Pancreatic toxicity

ASJC Scopus subject areas

  • Toxicology

Cite this

Selective pancreatic toxicity of palmitoylpentachlorophenol. / Ansari, Ghulam; Kaphalia, Bhupendra; Boor, P. J.

In: Toxicology, Vol. 46, No. 1, 12.10.1987, p. 57-63.

Research output: Contribution to journalArticle

@article{f5a69ed93f1f430d9186c186509e3aaa,
title = "Selective pancreatic toxicity of palmitoylpentachlorophenol",
abstract = "Palmitoylpentachlorophenol (PPCP), which is a lipid conjugate of a xenobiotic compound, has been found in human fat. To study the toxicity associated with PPCP, rats were given 100 mg/kg PPCP and sacrificed at 4, 8 and 12 days. The target organ identified was the exocrine pancreas; no other major organs examined showed any gross or histopathological abnormality. At 4 and 8 days after treatment, focal, spotty vacuolation, and loss of pancreatic acini was observed. Acute inflammatory infiltrate was also observed in parenchyma at all time points and the loss of acinar tissue was resolved through fibrous tissue formation by 12 days. The present study indicates that PPCP has a specific target organ toxicity.",
keywords = "fatty acid conjugate, Palmitoylpentachlorophenol, Pancreatic toxicity",
author = "Ghulam Ansari and Bhupendra Kaphalia and Boor, {P. J.}",
year = "1987",
month = "10",
day = "12",
doi = "10.1016/0300-483X(87)90137-5",
language = "English",
volume = "46",
pages = "57--63",
journal = "Toxicology",
issn = "0300-483X",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Selective pancreatic toxicity of palmitoylpentachlorophenol

AU - Ansari, Ghulam

AU - Kaphalia, Bhupendra

AU - Boor, P. J.

PY - 1987/10/12

Y1 - 1987/10/12

N2 - Palmitoylpentachlorophenol (PPCP), which is a lipid conjugate of a xenobiotic compound, has been found in human fat. To study the toxicity associated with PPCP, rats were given 100 mg/kg PPCP and sacrificed at 4, 8 and 12 days. The target organ identified was the exocrine pancreas; no other major organs examined showed any gross or histopathological abnormality. At 4 and 8 days after treatment, focal, spotty vacuolation, and loss of pancreatic acini was observed. Acute inflammatory infiltrate was also observed in parenchyma at all time points and the loss of acinar tissue was resolved through fibrous tissue formation by 12 days. The present study indicates that PPCP has a specific target organ toxicity.

AB - Palmitoylpentachlorophenol (PPCP), which is a lipid conjugate of a xenobiotic compound, has been found in human fat. To study the toxicity associated with PPCP, rats were given 100 mg/kg PPCP and sacrificed at 4, 8 and 12 days. The target organ identified was the exocrine pancreas; no other major organs examined showed any gross or histopathological abnormality. At 4 and 8 days after treatment, focal, spotty vacuolation, and loss of pancreatic acini was observed. Acute inflammatory infiltrate was also observed in parenchyma at all time points and the loss of acinar tissue was resolved through fibrous tissue formation by 12 days. The present study indicates that PPCP has a specific target organ toxicity.

KW - fatty acid conjugate

KW - Palmitoylpentachlorophenol

KW - Pancreatic toxicity

UR - http://www.scopus.com/inward/record.url?scp=0023241637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023241637&partnerID=8YFLogxK

U2 - 10.1016/0300-483X(87)90137-5

DO - 10.1016/0300-483X(87)90137-5

M3 - Article

C2 - 3660420

AN - SCOPUS:0023241637

VL - 46

SP - 57

EP - 63

JO - Toxicology

JF - Toxicology

SN - 0300-483X

IS - 1

ER -