Selective pancreatic toxicity of palmitoylpentachlorophenol

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13 Scopus citations

Abstract

Palmitoylpentachlorophenol (PPCP), which is a lipid conjugate of a xenobiotic compound, has been found in human fat. To study the toxicity associated with PPCP, rats were given 100 mg/kg PPCP and sacrificed at 4, 8 and 12 days. The target organ identified was the exocrine pancreas; no other major organs examined showed any gross or histopathological abnormality. At 4 and 8 days after treatment, focal, spotty vacuolation, and loss of pancreatic acini was observed. Acute inflammatory infiltrate was also observed in parenchyma at all time points and the loss of acinar tissue was resolved through fibrous tissue formation by 12 days. The present study indicates that PPCP has a specific target organ toxicity.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalToxicology
Volume46
Issue number1
DOIs
StatePublished - Oct 12 1987

Keywords

  • fatty acid conjugate
  • Palmitoylpentachlorophenol
  • Pancreatic toxicity

ASJC Scopus subject areas

  • Toxicology

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