Selective pancreatic toxicity of palmitoylpentachlorophenol

G. A.S. Ansari; B. S. Kaphalia; P. J. Boor

doi:10.1016/0300-483X(87)90137-5

Selective pancreatic toxicity of palmitoylpentachlorophenol

G. A.S. Ansari, B. S. Kaphalia, P. J. Boor

Pathology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Palmitoylpentachlorophenol (PPCP), which is a lipid conjugate of a xenobiotic compound, has been found in human fat. To study the toxicity associated with PPCP, rats were given 100 mg/kg PPCP and sacrificed at 4, 8 and 12 days. The target organ identified was the exocrine pancreas; no other major organs examined showed any gross or histopathological abnormality. At 4 and 8 days after treatment, focal, spotty vacuolation, and loss of pancreatic acini was observed. Acute inflammatory infiltrate was also observed in parenchyma at all time points and the loss of acinar tissue was resolved through fibrous tissue formation by 12 days. The present study indicates that PPCP has a specific target organ toxicity.

Original language	English (US)
Pages (from-to)	57-63
Number of pages	7
Journal	Toxicology
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/0300-483X(87)90137-5
State	Published - Oct 12 1987

Keywords

fatty acid conjugate
Palmitoylpentachlorophenol
Pancreatic toxicity

ASJC Scopus subject areas

Toxicology

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10.1016/0300-483X(87)90137-5

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title = "Selective pancreatic toxicity of palmitoylpentachlorophenol",

abstract = "Palmitoylpentachlorophenol (PPCP), which is a lipid conjugate of a xenobiotic compound, has been found in human fat. To study the toxicity associated with PPCP, rats were given 100 mg/kg PPCP and sacrificed at 4, 8 and 12 days. The target organ identified was the exocrine pancreas; no other major organs examined showed any gross or histopathological abnormality. At 4 and 8 days after treatment, focal, spotty vacuolation, and loss of pancreatic acini was observed. Acute inflammatory infiltrate was also observed in parenchyma at all time points and the loss of acinar tissue was resolved through fibrous tissue formation by 12 days. The present study indicates that PPCP has a specific target organ toxicity.",

keywords = "fatty acid conjugate, Palmitoylpentachlorophenol, Pancreatic toxicity",

author = "Ansari, {G. A.S.} and Kaphalia, {B. S.} and Boor, {P. J.}",

note = "Funding Information: This investigation was supported in part by grant OH 02149, awarded by the National Institute for Occupational Safety and Health of the Centers for Disease Control; U.S.P.H.S. grant DK 27135, awarded by the National Institute of Diabetes, Digestive and Kidney Diseases, and HL 26189, awarded by the National Heart and Lung Institute. The authors wish to thank Ms. Avis Morgan for secretarial assistance.",

year = "1987",

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doi = "10.1016/0300-483X(87)90137-5",

language = "English (US)",

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T1 - Selective pancreatic toxicity of palmitoylpentachlorophenol

AU - Ansari, G. A.S.

AU - Kaphalia, B. S.

AU - Boor, P. J.

N1 - Funding Information: This investigation was supported in part by grant OH 02149, awarded by the National Institute for Occupational Safety and Health of the Centers for Disease Control; U.S.P.H.S. grant DK 27135, awarded by the National Institute of Diabetes, Digestive and Kidney Diseases, and HL 26189, awarded by the National Heart and Lung Institute. The authors wish to thank Ms. Avis Morgan for secretarial assistance.

PY - 1987/10/12

Y1 - 1987/10/12

N2 - Palmitoylpentachlorophenol (PPCP), which is a lipid conjugate of a xenobiotic compound, has been found in human fat. To study the toxicity associated with PPCP, rats were given 100 mg/kg PPCP and sacrificed at 4, 8 and 12 days. The target organ identified was the exocrine pancreas; no other major organs examined showed any gross or histopathological abnormality. At 4 and 8 days after treatment, focal, spotty vacuolation, and loss of pancreatic acini was observed. Acute inflammatory infiltrate was also observed in parenchyma at all time points and the loss of acinar tissue was resolved through fibrous tissue formation by 12 days. The present study indicates that PPCP has a specific target organ toxicity.

AB - Palmitoylpentachlorophenol (PPCP), which is a lipid conjugate of a xenobiotic compound, has been found in human fat. To study the toxicity associated with PPCP, rats were given 100 mg/kg PPCP and sacrificed at 4, 8 and 12 days. The target organ identified was the exocrine pancreas; no other major organs examined showed any gross or histopathological abnormality. At 4 and 8 days after treatment, focal, spotty vacuolation, and loss of pancreatic acini was observed. Acute inflammatory infiltrate was also observed in parenchyma at all time points and the loss of acinar tissue was resolved through fibrous tissue formation by 12 days. The present study indicates that PPCP has a specific target organ toxicity.

KW - fatty acid conjugate

KW - Palmitoylpentachlorophenol

KW - Pancreatic toxicity

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Selective pancreatic toxicity of palmitoylpentachlorophenol

Abstract

Keywords

ASJC Scopus subject areas

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