Selective reduction of human tumor cell populations by human granulocytes in vitro

Courtney Townsend, C. M. Townsend, M. A. Galbraith, F. R. Eilber, D. L. Morton

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Human peripheral blood granulocytes at a 10:1 effector cell:target cell ratio were shown by an in vitro semiquantitative staining procedure to reduce the number of human tumor cells, but not that of normal cells. Microscopic observations revealed that this selective reduction of tumor cells by granulocytes was a function of both detachment and cytolysis. The cytotoxic effect of granulocytes on the tumor cells was confirmed by a quantitative 5-[ 125I]iodo-2-deoxyuridine release assay. The data indicate that human granulocytes at a relatively low effector:target cell ratio (10:1) have the capacity to recognize and destroy human tumor cells in vitro.

Original languageEnglish (US)
Pages (from-to)4534-4539
Number of pages6
JournalCancer Research
Volume38
Issue number12
StatePublished - 1978
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Townsend, C., Townsend, C. M., Galbraith, M. A., Eilber, F. R., & Morton, D. L. (1978). Selective reduction of human tumor cell populations by human granulocytes in vitro. Cancer Research, 38(12), 4534-4539.