Selective reduction of human tumor cell populations by human granulocytes in vitro

Courtney Townsend, C. M. Townsend, M. A. Galbraith, F. R. Eilber, D. L. Morton

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Human peripheral blood granulocytes at a 10:1 effector cell:target cell ratio were shown by an in vitro semiquantitative staining procedure to reduce the number of human tumor cells, but not that of normal cells. Microscopic observations revealed that this selective reduction of tumor cells by granulocytes was a function of both detachment and cytolysis. The cytotoxic effect of granulocytes on the tumor cells was confirmed by a quantitative 5-[ 125I]iodo-2-deoxyuridine release assay. The data indicate that human granulocytes at a relatively low effector:target cell ratio (10:1) have the capacity to recognize and destroy human tumor cells in vitro.

Original languageEnglish (US)
Pages (from-to)4534-4539
Number of pages6
JournalCancer Research
Volume38
Issue number12
StatePublished - 1978
Externally publishedYes

Fingerprint

Granulocytes
Population
Neoplasms
Deoxyuridine
In Vitro Techniques
Staining and Labeling

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Townsend, C., Townsend, C. M., Galbraith, M. A., Eilber, F. R., & Morton, D. L. (1978). Selective reduction of human tumor cell populations by human granulocytes in vitro. Cancer Research, 38(12), 4534-4539.

Selective reduction of human tumor cell populations by human granulocytes in vitro. / Townsend, Courtney; Townsend, C. M.; Galbraith, M. A.; Eilber, F. R.; Morton, D. L.

In: Cancer Research, Vol. 38, No. 12, 1978, p. 4534-4539.

Research output: Contribution to journalArticle

Townsend, C, Townsend, CM, Galbraith, MA, Eilber, FR & Morton, DL 1978, 'Selective reduction of human tumor cell populations by human granulocytes in vitro', Cancer Research, vol. 38, no. 12, pp. 4534-4539.
Townsend C, Townsend CM, Galbraith MA, Eilber FR, Morton DL. Selective reduction of human tumor cell populations by human granulocytes in vitro. Cancer Research. 1978;38(12):4534-4539.
Townsend, Courtney ; Townsend, C. M. ; Galbraith, M. A. ; Eilber, F. R. ; Morton, D. L. / Selective reduction of human tumor cell populations by human granulocytes in vitro. In: Cancer Research. 1978 ; Vol. 38, No. 12. pp. 4534-4539.
@article{6515ec4bdda946da88c6505e821efdec,
title = "Selective reduction of human tumor cell populations by human granulocytes in vitro",
abstract = "Human peripheral blood granulocytes at a 10:1 effector cell:target cell ratio were shown by an in vitro semiquantitative staining procedure to reduce the number of human tumor cells, but not that of normal cells. Microscopic observations revealed that this selective reduction of tumor cells by granulocytes was a function of both detachment and cytolysis. The cytotoxic effect of granulocytes on the tumor cells was confirmed by a quantitative 5-[ 125I]iodo-2-deoxyuridine release assay. The data indicate that human granulocytes at a relatively low effector:target cell ratio (10:1) have the capacity to recognize and destroy human tumor cells in vitro.",
author = "Courtney Townsend and Townsend, {C. M.} and Galbraith, {M. A.} and Eilber, {F. R.} and Morton, {D. L.}",
year = "1978",
language = "English (US)",
volume = "38",
pages = "4534--4539",
journal = "Journal of Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "12",

}

TY - JOUR

T1 - Selective reduction of human tumor cell populations by human granulocytes in vitro

AU - Townsend, Courtney

AU - Townsend, C. M.

AU - Galbraith, M. A.

AU - Eilber, F. R.

AU - Morton, D. L.

PY - 1978

Y1 - 1978

N2 - Human peripheral blood granulocytes at a 10:1 effector cell:target cell ratio were shown by an in vitro semiquantitative staining procedure to reduce the number of human tumor cells, but not that of normal cells. Microscopic observations revealed that this selective reduction of tumor cells by granulocytes was a function of both detachment and cytolysis. The cytotoxic effect of granulocytes on the tumor cells was confirmed by a quantitative 5-[ 125I]iodo-2-deoxyuridine release assay. The data indicate that human granulocytes at a relatively low effector:target cell ratio (10:1) have the capacity to recognize and destroy human tumor cells in vitro.

AB - Human peripheral blood granulocytes at a 10:1 effector cell:target cell ratio were shown by an in vitro semiquantitative staining procedure to reduce the number of human tumor cells, but not that of normal cells. Microscopic observations revealed that this selective reduction of tumor cells by granulocytes was a function of both detachment and cytolysis. The cytotoxic effect of granulocytes on the tumor cells was confirmed by a quantitative 5-[ 125I]iodo-2-deoxyuridine release assay. The data indicate that human granulocytes at a relatively low effector:target cell ratio (10:1) have the capacity to recognize and destroy human tumor cells in vitro.

UR - http://www.scopus.com/inward/record.url?scp=0018141567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018141567&partnerID=8YFLogxK

M3 - Article

VL - 38

SP - 4534

EP - 4539

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0008-5472

IS - 12

ER -