Self-contained diffuse optical imaging system for real-time detection and localization of vascular occlusions

Luca Pollonini, Kiefer J. Forseth, Clifford C. Dacso, Scott E. Parazynski, Jeffrey D. Friedman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Free flap surgery is a procedure where healthy tissue is transferred from a donor site to a recipient site of the body to fill a defect without maintaining the original blood supply to the flap. The anastomosis of the vascular network of the flap to the blood vessels adjacent to the recipient site has associated risks of arterial and/or venous occlusions that must be promptly detected to avoid temporary or permanent tissue damage. In this work, we present a skin-contact diffusion optical imaging (DOI) system able to continuously provide a three-dimensional representation of the flap oxygenation to promptly detect vascular occlusions potentially occurring in the flap. Multiple near-infrared LEDs and photodetectors were embedded into a self-contained optical sensor for prolonged monitoring of concentration changes of oxygenated (HbO) and deoxygenated hemoglobin (HbR) at multiple locations and depths. A time-efficient algorithm mapped measured oxygenation changes in a three-dimensional volume to allow surgeons and clinical personnel to detect and localize abnormal blood perfusion changes during or after surgery, in time for corrective intervention. The image reconstruction algorithm was validated using computerized flap models in which oxygenation was synthetically altered, whereas the optical system was preliminarily tested on a healthy forearm simulating a flap undergoing arterial and venous occlusions, proving the feasibility of implementing DOI in the form of a wearable patch for prolonged perfusion monitoring.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages5884-5887
Number of pages4
Volume2015-November
ISBN (Print)9781424492718
DOIs
StatePublished - Nov 4 2015
Externally publishedYes
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: Aug 25 2015Aug 29 2015

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period8/25/158/29/15

Fingerprint

Optical Devices
Oxygenation
Optical Imaging
Imaging systems
Blood Vessels
Surgery
Blood
Perfusion
Tissue
Computer-Assisted Image Processing
Free Tissue Flaps
Monitoring
Hemoglobin
Blood vessels
Optical sensors
Photodetectors
Image reconstruction
Forearm
Optical systems
Computer Simulation

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Pollonini, L., Forseth, K. J., Dacso, C. C., Parazynski, S. E., & Friedman, J. D. (2015). Self-contained diffuse optical imaging system for real-time detection and localization of vascular occlusions. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 5884-5887). [7319730] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319730

Self-contained diffuse optical imaging system for real-time detection and localization of vascular occlusions. / Pollonini, Luca; Forseth, Kiefer J.; Dacso, Clifford C.; Parazynski, Scott E.; Friedman, Jeffrey D.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. p. 5884-5887 7319730.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pollonini, L, Forseth, KJ, Dacso, CC, Parazynski, SE & Friedman, JD 2015, Self-contained diffuse optical imaging system for real-time detection and localization of vascular occlusions. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. vol. 2015-November, 7319730, Institute of Electrical and Electronics Engineers Inc., pp. 5884-5887, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 8/25/15. https://doi.org/10.1109/EMBC.2015.7319730
Pollonini L, Forseth KJ, Dacso CC, Parazynski SE, Friedman JD. Self-contained diffuse optical imaging system for real-time detection and localization of vascular occlusions. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November. Institute of Electrical and Electronics Engineers Inc. 2015. p. 5884-5887. 7319730 https://doi.org/10.1109/EMBC.2015.7319730
Pollonini, Luca ; Forseth, Kiefer J. ; Dacso, Clifford C. ; Parazynski, Scott E. ; Friedman, Jeffrey D. / Self-contained diffuse optical imaging system for real-time detection and localization of vascular occlusions. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. pp. 5884-5887
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