Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors

Rinat Esenaliev, Alexander A. Karabutov, Alexander A. Oraevsky

Research output: Contribution to journalArticle

242 Citations (Scopus)

Abstract

Current imaging modalities fail to detect small tumors in the breast. Opto-acoustic tomography is a novel technique for early cancer detection with promising diagnostic capability. The experimental limit of sensitivity and maximal depth of the laser opto-acoustic detection for small model tumors located within bulk phantom tissue were studied. Two phantoms with optical properties similar to that of breast tissue in the near infrared spectral range were used in these studies: turbid gelatin slabs with the thickness of 100 mm and chicken breast muscle slabs with the thickness of up to 80 mm. Gelatin spheres with enhanced absorption coefficient relative to the background absorption and liver tissue were used to simulate small tumors. The experiments demonstrated the capability of laser optoacoustic imaging to detect and localize phantom tumors with the diameter of 2 mm at a depth of up to 60 mm within the gelatin phantoms and 3 × 2 × 0.6-mm piece of liver tissue within 80-mm chicken breast tissue. Theoretical studies on sensitivity of opto-acoustic detection at various diameters, depths of location, and absorption coefficients of small tumors were performed using the experimental data. Our results suggest that the opto-acoustic imaging may occupy a significant niche in early detection of cancer in the breast and other organs.

Original languageEnglish (US)
Pages (from-to)981-988
Number of pages8
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume5
Issue number4
DOIs
StatePublished - Jul 1999

Fingerprint

Acoustic imaging
acoustic imaging
breast
Tumors
tumors
Tissue
gelatins
Lasers
sensitivity
sound detecting and ranging
chickens
Acoustics
lasers
liver
Liver
absorptivity
slabs
cancer
Imaging techniques
Photoacoustic effect

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics

Cite this

Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors. / Esenaliev, Rinat; Karabutov, Alexander A.; Oraevsky, Alexander A.

In: IEEE Journal on Selected Topics in Quantum Electronics, Vol. 5, No. 4, 07.1999, p. 981-988.

Research output: Contribution to journalArticle

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