Sensory Responsiveness in Siblings of Children with Autism Spectrum Disorders

Claudia Hilton, Alison Babb-Keeble, Erin Eitzmann Westover, Yi Zhang, Claire Adams, Diane Collins, Amol Karmarkar, Timothy Reistetter, John N. Constantino

Research output: Contribution to journalArticle

Abstract

This study examined sensory responsiveness in unaffected siblings of children with autism spectrum disorder (ASD) and associations between sensory responsiveness and social severity. Sensory Profile Caregiver Questionnaires and Social Responsiveness Scales were completed by parents of 185 children between age 4 and 10.95 years. Significant differences were found between participants with ASD and controls, and between participants with ASD and unaffected siblings for all sensory quadrants and domains, but not between controls and unaffected siblings. Social responsiveness scores were significantly correlated with scores from most sensory profile categories. Sensory responsiveness as an endophenotype of ASD is not indicated from these findings; however, studies with larger numbers of unaffected siblings and controls are needed to confirm the null hypothesis.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of Autism and Developmental Disorders
DOIs
StateAccepted/In press - Oct 4 2016

Fingerprint

Siblings
Endophenotypes
Caregivers
Parents
Autism Spectrum Disorder

Keywords

  • Autism
  • Endophenotype
  • Family
  • Genetics
  • Sensory responsiveness

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Cite this

Sensory Responsiveness in Siblings of Children with Autism Spectrum Disorders. / Hilton, Claudia; Babb-Keeble, Alison; Westover, Erin Eitzmann; Zhang, Yi; Adams, Claire; Collins, Diane; Karmarkar, Amol; Reistetter, Timothy; Constantino, John N.

In: Journal of Autism and Developmental Disorders, 04.10.2016, p. 1-10.

Research output: Contribution to journalArticle

Hilton, Claudia ; Babb-Keeble, Alison ; Westover, Erin Eitzmann ; Zhang, Yi ; Adams, Claire ; Collins, Diane ; Karmarkar, Amol ; Reistetter, Timothy ; Constantino, John N. / Sensory Responsiveness in Siblings of Children with Autism Spectrum Disorders. In: Journal of Autism and Developmental Disorders. 2016 ; pp. 1-10.
@article{d6949ef1844a473881b8ecde180493cd,
title = "Sensory Responsiveness in Siblings of Children with Autism Spectrum Disorders",
abstract = "This study examined sensory responsiveness in unaffected siblings of children with autism spectrum disorder (ASD) and associations between sensory responsiveness and social severity. Sensory Profile Caregiver Questionnaires and Social Responsiveness Scales were completed by parents of 185 children between age 4 and 10.95 years. Significant differences were found between participants with ASD and controls, and between participants with ASD and unaffected siblings for all sensory quadrants and domains, but not between controls and unaffected siblings. Social responsiveness scores were significantly correlated with scores from most sensory profile categories. Sensory responsiveness as an endophenotype of ASD is not indicated from these findings; however, studies with larger numbers of unaffected siblings and controls are needed to confirm the null hypothesis.",
keywords = "Autism, Endophenotype, Family, Genetics, Sensory responsiveness",
author = "Claudia Hilton and Alison Babb-Keeble and Westover, {Erin Eitzmann} and Yi Zhang and Claire Adams and Diane Collins and Amol Karmarkar and Timothy Reistetter and Constantino, {John N.}",
year = "2016",
month = "10",
day = "4",
doi = "10.1007/s10803-016-2918-y",
language = "English (US)",
pages = "1--10",
journal = "Journal of Autism and Developmental Disorders",
issn = "0162-3257",
publisher = "Springer New York",

}

TY - JOUR

T1 - Sensory Responsiveness in Siblings of Children with Autism Spectrum Disorders

AU - Hilton, Claudia

AU - Babb-Keeble, Alison

AU - Westover, Erin Eitzmann

AU - Zhang, Yi

AU - Adams, Claire

AU - Collins, Diane

AU - Karmarkar, Amol

AU - Reistetter, Timothy

AU - Constantino, John N.

PY - 2016/10/4

Y1 - 2016/10/4

N2 - This study examined sensory responsiveness in unaffected siblings of children with autism spectrum disorder (ASD) and associations between sensory responsiveness and social severity. Sensory Profile Caregiver Questionnaires and Social Responsiveness Scales were completed by parents of 185 children between age 4 and 10.95 years. Significant differences were found between participants with ASD and controls, and between participants with ASD and unaffected siblings for all sensory quadrants and domains, but not between controls and unaffected siblings. Social responsiveness scores were significantly correlated with scores from most sensory profile categories. Sensory responsiveness as an endophenotype of ASD is not indicated from these findings; however, studies with larger numbers of unaffected siblings and controls are needed to confirm the null hypothesis.

AB - This study examined sensory responsiveness in unaffected siblings of children with autism spectrum disorder (ASD) and associations between sensory responsiveness and social severity. Sensory Profile Caregiver Questionnaires and Social Responsiveness Scales were completed by parents of 185 children between age 4 and 10.95 years. Significant differences were found between participants with ASD and controls, and between participants with ASD and unaffected siblings for all sensory quadrants and domains, but not between controls and unaffected siblings. Social responsiveness scores were significantly correlated with scores from most sensory profile categories. Sensory responsiveness as an endophenotype of ASD is not indicated from these findings; however, studies with larger numbers of unaffected siblings and controls are needed to confirm the null hypothesis.

KW - Autism

KW - Endophenotype

KW - Family

KW - Genetics

KW - Sensory responsiveness

UR - http://www.scopus.com/inward/record.url?scp=84990866802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84990866802&partnerID=8YFLogxK

U2 - 10.1007/s10803-016-2918-y

DO - 10.1007/s10803-016-2918-y

M3 - Article

SP - 1

EP - 10

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

SN - 0162-3257

ER -