Sentinel lymph node biopsy for staging breast cancer

Isabel T. Rubio, Soheila Korourian, Christopher Cowan, David N. Krag, Maureen Colvert, Vicki Klimberg

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

BACKGROUND: Determination of axillary nodal status is essential for the staging of breast cancer since nodal status is one of the most important predictors of survival. The objective of this study was to test the hypothesis that the histology of the first draining lymph node (LN) accurately predicts the histology of the rest of the axillary LNs. METHODS: Fifty-five patients with operable invasive breast carcinoma and clinically negative axillary lymph nodes were studied. Patients were injected with Technetium-99 (99Tc) sulfur colloid around the primary tumor. A hand-held gamma detector probe was used to identify the sentinel LN (SLN). After the SLN was identified and removed, a level I and II lymphadenectomy was performed. RESULTS: The SLN was identified in 53 (96.3%) of the 55 patients entered into the trial. The sensitivity was 88.2% and the specificity was 100%. The positive predictive value was 100% and the negative predictive value was 94.6%. The accuracy of the study was 96.2%. CONCLUSIONS: The SLN biopsy for breast cancer staging is highly accurate in our hands and has the potential to decrease the morbidity and cost of managing patients with breast cancer without compromise of staging.

Original languageEnglish (US)
Pages (from-to)532-537
Number of pages6
JournalAmerican Journal of Surgery
Volume176
Issue number6
DOIs
StatePublished - 1998
Externally publishedYes

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Sentinel Lymph Node Biopsy
Breast Neoplasms
Histology
Lymph Nodes
Neoplasm Staging
Technetium
Colloids
Lymph Node Excision
Sulfur
Hand
Morbidity
Biopsy
Costs and Cost Analysis
Survival
cyhalothrin
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Rubio, I. T., Korourian, S., Cowan, C., Krag, D. N., Colvert, M., & Klimberg, V. (1998). Sentinel lymph node biopsy for staging breast cancer. American Journal of Surgery, 176(6), 532-537. https://doi.org/10.1016/S0002-9610(98)00264-5

Sentinel lymph node biopsy for staging breast cancer. / Rubio, Isabel T.; Korourian, Soheila; Cowan, Christopher; Krag, David N.; Colvert, Maureen; Klimberg, Vicki.

In: American Journal of Surgery, Vol. 176, No. 6, 1998, p. 532-537.

Research output: Contribution to journalArticle

Rubio, IT, Korourian, S, Cowan, C, Krag, DN, Colvert, M & Klimberg, V 1998, 'Sentinel lymph node biopsy for staging breast cancer', American Journal of Surgery, vol. 176, no. 6, pp. 532-537. https://doi.org/10.1016/S0002-9610(98)00264-5
Rubio, Isabel T. ; Korourian, Soheila ; Cowan, Christopher ; Krag, David N. ; Colvert, Maureen ; Klimberg, Vicki. / Sentinel lymph node biopsy for staging breast cancer. In: American Journal of Surgery. 1998 ; Vol. 176, No. 6. pp. 532-537.
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N2 - BACKGROUND: Determination of axillary nodal status is essential for the staging of breast cancer since nodal status is one of the most important predictors of survival. The objective of this study was to test the hypothesis that the histology of the first draining lymph node (LN) accurately predicts the histology of the rest of the axillary LNs. METHODS: Fifty-five patients with operable invasive breast carcinoma and clinically negative axillary lymph nodes were studied. Patients were injected with Technetium-99 (99Tc) sulfur colloid around the primary tumor. A hand-held gamma detector probe was used to identify the sentinel LN (SLN). After the SLN was identified and removed, a level I and II lymphadenectomy was performed. RESULTS: The SLN was identified in 53 (96.3%) of the 55 patients entered into the trial. The sensitivity was 88.2% and the specificity was 100%. The positive predictive value was 100% and the negative predictive value was 94.6%. The accuracy of the study was 96.2%. CONCLUSIONS: The SLN biopsy for breast cancer staging is highly accurate in our hands and has the potential to decrease the morbidity and cost of managing patients with breast cancer without compromise of staging.

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