Sepsis

Luis Pacheco, Joost J. Zwart

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Sepsis and pregnancy, Sepsis occurs as the result of a systemic maladaptive inflammatory response to an infectious insult. It is the leading cause of mortality in intensive care units (ICUs) in developed countries and the incidence is increasing worldwide [1]. Sepsis is also one of the leading causes of maternal mortality [2]. The incidence of death from severe sepsis in the obstetric population is lower than that of non-obstetric patients. The latter is likely secondary to a younger population with less coexisting medical pathologies. Pregnancy affects both humoral and cell-mediated immunological functions. The white blood cell count rises as pregnancy progresses, and some authors have described these neutrophils as “activated,” favoring severe inflammatory reactions to infectious stimuli [3]. Cellular immunity is compromised as a consequence of the decline in T-helper type 1 and natural killer cells. The decrease in cellular immunity predisposes pregnant women to infections from viruses and parasites. In contrast, antibody-mediated immunity is enhanced in pregnancy despite the fact that levels of immunoglobulins are depressed (likely from hemodilution). Pregnancy is not a state of generalized immunosuppression, instead, it is a state of immunomodulation, with compromised cellular and enhanced humoral immunity.

Original languageEnglish (US)
Title of host publicationMaternal Critical Care: A Multidisciplinary Approach
PublisherCambridge University Press
Pages346-355
Number of pages10
ISBN (Print)9781139088084, 9781107018495
DOIs
StatePublished - Jan 1 2011

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Sepsis
Pregnancy
Cellular Immunity
Hemodilution
Parasitic Diseases
Immunomodulation
Maternal Mortality
Incidence
Virus Diseases
Humoral Immunity
Leukocyte Count
Developed Countries
Natural Killer Cells
Immunosuppression
Population
Obstetrics
Intensive Care Units
Immunoglobulins
Pregnant Women
Immunity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pacheco, L., & Zwart, J. J. (2011). Sepsis. In Maternal Critical Care: A Multidisciplinary Approach (pp. 346-355). Cambridge University Press. https://doi.org/10.1017/CBO9781139088084.032

Sepsis. / Pacheco, Luis; Zwart, Joost J.

Maternal Critical Care: A Multidisciplinary Approach. Cambridge University Press, 2011. p. 346-355.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pacheco, L & Zwart, JJ 2011, Sepsis. in Maternal Critical Care: A Multidisciplinary Approach. Cambridge University Press, pp. 346-355. https://doi.org/10.1017/CBO9781139088084.032
Pacheco L, Zwart JJ. Sepsis. In Maternal Critical Care: A Multidisciplinary Approach. Cambridge University Press. 2011. p. 346-355 https://doi.org/10.1017/CBO9781139088084.032
Pacheco, Luis ; Zwart, Joost J. / Sepsis. Maternal Critical Care: A Multidisciplinary Approach. Cambridge University Press, 2011. pp. 346-355
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