Septal function during left ventricular unloading

Marc R. Moon, Ann F. Bolger, Abelardo DeAnda, Masashi Komeda, George T. Daughters, Srdjan D. Nikolic, D. Craig Miller, Neil B. Ingels

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: Left ventricular (LV) unloading with mechanical support devices alters biventricular geometry and impairs right ventricular (RV) contractility, but its effect on septal systolic function remains unknown. Methods and Results: To evaluate the effects of LV volume and pressure unloading on septal geometry and function, LV preload was abruptly reduced by clamping left atrial pressure between 0 and -2 mm Hg in seven open- chest, anesthetized dogs by use of a pressure-control servomechanism to withdraw blood from the left atrium. With left atrial pressure clamping, maximal LV pressure decreased 30±12% (mean±SD) (P

Original languageEnglish (US)
Pages (from-to)1320-1327
Number of pages8
JournalCirculation
Volume95
Issue number5
StatePublished - 1997
Externally publishedYes

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Atrial Pressure
Ventricular Pressure
Left Ventricular Function
Constriction
Heart Atria
Thorax
Dogs
Pressure
Equipment and Supplies

Keywords

  • echocardiography
  • heart-assist device
  • mechanics
  • ventricles

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Moon, M. R., Bolger, A. F., DeAnda, A., Komeda, M., Daughters, G. T., Nikolic, S. D., ... Ingels, N. B. (1997). Septal function during left ventricular unloading. Circulation, 95(5), 1320-1327.

Septal function during left ventricular unloading. / Moon, Marc R.; Bolger, Ann F.; DeAnda, Abelardo; Komeda, Masashi; Daughters, George T.; Nikolic, Srdjan D.; Miller, D. Craig; Ingels, Neil B.

In: Circulation, Vol. 95, No. 5, 1997, p. 1320-1327.

Research output: Contribution to journalArticle

Moon, MR, Bolger, AF, DeAnda, A, Komeda, M, Daughters, GT, Nikolic, SD, Miller, DC & Ingels, NB 1997, 'Septal function during left ventricular unloading', Circulation, vol. 95, no. 5, pp. 1320-1327.
Moon MR, Bolger AF, DeAnda A, Komeda M, Daughters GT, Nikolic SD et al. Septal function during left ventricular unloading. Circulation. 1997;95(5):1320-1327.
Moon, Marc R. ; Bolger, Ann F. ; DeAnda, Abelardo ; Komeda, Masashi ; Daughters, George T. ; Nikolic, Srdjan D. ; Miller, D. Craig ; Ingels, Neil B. / Septal function during left ventricular unloading. In: Circulation. 1997 ; Vol. 95, No. 5. pp. 1320-1327.
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AU - Miller, D. Craig

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