Septic shock: Pathogenesis and treatment

Leticia Castillo, Melchor Sanchez

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Septic shock is the host's inflammatory response to infection. There are multiple endogenous mediators responsible for the pathogenesis of septic shock. Cytokines, nitric oxide and prostaglandins are some of the major mediators. The term sepsis syndrome allows for an earlier diagnosis and treatment. Management of septic shock is focused in maintaining hemodynamic stability and an adequate oxygen delivery and utilization. Careful attention to each organ-system is of paramount importance to prevent complications and improve outcome. Experimental therapies to modulate the inflammatory response are promising.

Original languageEnglish (US)
Pages (from-to)367-379
Number of pages13
JournalThe Indian Journal of Pediatrics
Issue number3
StatePublished - May 1993
Externally publishedYes


  • Critically ill
  • Sepsis syndrome
  • Septic shock

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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