Sequelae to acromegaly: Reversibility with treatment of the primary disease

S. A. Lieberman, A. R. Hoffman

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Acromegalic patients suffer from a number of cardiovascular, metabolic, and rheumatologic problems, and they may also have an increased incidence of malignancy. We reviewed the literature concerning the reversibility of acromegalic complications. Hypertension, myorcardial hypertrophy, left ventricular dysfunction and some rheumatologic abnormalities often continue despite successful treatment of the acromegaly. In contrast, glucose intolerance, soft tissue changes, and carpal tunnel syndrome usually resolve when the acromegaly is cured. Studies of the incidence and mortality of cancer in acromegaly are conflicting, but several suggest an increased incidence of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalHormone and Metabolic Research
Issue number6
StatePublished - 1990
Externally publishedYes


  • acromegaly
  • cardiomyopathy
  • carpal tunnel syndrome
  • colorectal cancer
  • diabetes mellitus
  • hypertension
  • malignancy
  • osteoarthritis
  • ventricular hypertrophy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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