TY - JOUR
T1 - Sequential ventricular fluid concentrations of ceftazidime
T2 - Report of three cases
AU - Polk, R. E.
AU - Mayhall, C. G.
AU - Tartaglione, T.
AU - Baggett, J.
AU - Patterson, P.
PY - 1984
Y1 - 1984
N2 - Three adult subjects, each with a ventriculostomy, received ceftazidime 2g iv q8h for three doses. Serial samples of serum and CSF ventricular fluid were obtained following the third dose; ceftazidime concentrations were measured by high pressure liquid chromatography. In one patient without inflammatory cells in the CSF, ceftazidime CSF concentrations were only ~0.3 μg/ml. In two other patients who had inflammatory cells and blood in the CSF, concentrations of ceftazidime in ventricular fluid demonstrated a slow rise and decline over a eight-hour period. Although contamination of the CSF by blood in these two patients confounds the interpretation of the concentrations achieved, it is concluded that obtaining serial samples of CSF from a ventriculostomy offers a more realistic appraisal of the dynamics of antibiotic penetration compared with the single-point method.
AB - Three adult subjects, each with a ventriculostomy, received ceftazidime 2g iv q8h for three doses. Serial samples of serum and CSF ventricular fluid were obtained following the third dose; ceftazidime concentrations were measured by high pressure liquid chromatography. In one patient without inflammatory cells in the CSF, ceftazidime CSF concentrations were only ~0.3 μg/ml. In two other patients who had inflammatory cells and blood in the CSF, concentrations of ceftazidime in ventricular fluid demonstrated a slow rise and decline over a eight-hour period. Although contamination of the CSF by blood in these two patients confounds the interpretation of the concentrations achieved, it is concluded that obtaining serial samples of CSF from a ventriculostomy offers a more realistic appraisal of the dynamics of antibiotic penetration compared with the single-point method.
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U2 - 10.1177/106002808401801209
DO - 10.1177/106002808401801209
M3 - Article
C2 - 6391885
AN - SCOPUS:0021714385
SN - 0012-6578
VL - 18
SP - 984
EP - 987
JO - Drug Intelligence and Clinical Pharmacy
JF - Drug Intelligence and Clinical Pharmacy
IS - 12
ER -