Sequential ventricular fluid concentrations of ceftazidime: Report of three cases

R. E. Polk, C. G. Mayhall, T. Tartaglione, J. Baggett, P. Patterson

Research output: Contribution to journalArticle

Abstract

Three adult subjects, each with a ventriculostomy, received ceftazidime 2g iv q8h for three doses. Serial samples of serum and CSF ventricular fluid were obtained following the third dose; ceftazidime concentrations were measured by high pressure liquid chromatography. In one patient without inflammatory cells in the CSF, ceftazidime CSF concentrations were only ~0.3 μg/ml. In two other patients who had inflammatory cells and blood in the CSF, concentrations of ceftazidime in ventricular fluid demonstrated a slow rise and decline over a eight-hour period. Although contamination of the CSF by blood in these two patients confounds the interpretation of the concentrations achieved, it is concluded that obtaining serial samples of CSF from a ventriculostomy offers a more realistic appraisal of the dynamics of antibiotic penetration compared with the single-point method.

Original languageEnglish (US)
Pages (from-to)984-987
Number of pages4
JournalDrug Intelligence and Clinical Pharmacy
Volume18
Issue number12
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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