Sequential ventricular fluid concentrations of ceftazidime: Report of three cases

R. E. Polk, C. G. Mayhall, T. Tartaglione, J. Baggett, P. Patterson

Research output: Contribution to journalArticle

Abstract

Three adult subjects, each with a ventriculostomy, received ceftazidime 2g iv q8h for three doses. Serial samples of serum and CSF ventricular fluid were obtained following the third dose; ceftazidime concentrations were measured by high pressure liquid chromatography. In one patient without inflammatory cells in the CSF, ceftazidime CSF concentrations were only ~0.3 μg/ml. In two other patients who had inflammatory cells and blood in the CSF, concentrations of ceftazidime in ventricular fluid demonstrated a slow rise and decline over a eight-hour period. Although contamination of the CSF by blood in these two patients confounds the interpretation of the concentrations achieved, it is concluded that obtaining serial samples of CSF from a ventriculostomy offers a more realistic appraisal of the dynamics of antibiotic penetration compared with the single-point method.

Original languageEnglish (US)
Pages (from-to)984-987
Number of pages4
JournalDrug Intelligence and Clinical Pharmacy
Volume18
Issue number12
StatePublished - 1984
Externally publishedYes

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Ceftazidime
Ventriculostomy
Blood Cells
High Pressure Liquid Chromatography
Anti-Bacterial Agents
Serum

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Polk, R. E., Mayhall, C. G., Tartaglione, T., Baggett, J., & Patterson, P. (1984). Sequential ventricular fluid concentrations of ceftazidime: Report of three cases. Drug Intelligence and Clinical Pharmacy, 18(12), 984-987.

Sequential ventricular fluid concentrations of ceftazidime : Report of three cases. / Polk, R. E.; Mayhall, C. G.; Tartaglione, T.; Baggett, J.; Patterson, P.

In: Drug Intelligence and Clinical Pharmacy, Vol. 18, No. 12, 1984, p. 984-987.

Research output: Contribution to journalArticle

Polk, RE, Mayhall, CG, Tartaglione, T, Baggett, J & Patterson, P 1984, 'Sequential ventricular fluid concentrations of ceftazidime: Report of three cases', Drug Intelligence and Clinical Pharmacy, vol. 18, no. 12, pp. 984-987.
Polk RE, Mayhall CG, Tartaglione T, Baggett J, Patterson P. Sequential ventricular fluid concentrations of ceftazidime: Report of three cases. Drug Intelligence and Clinical Pharmacy. 1984;18(12):984-987.
Polk, R. E. ; Mayhall, C. G. ; Tartaglione, T. ; Baggett, J. ; Patterson, P. / Sequential ventricular fluid concentrations of ceftazidime : Report of three cases. In: Drug Intelligence and Clinical Pharmacy. 1984 ; Vol. 18, No. 12. pp. 984-987.
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