Serial liver biopsy observations in hepatitis B antigen carriers by light and electron microscopy

Shih Chien Sun, R. Palmer Beasley, Karl E. Anderson, Howard S. Berg, Chi Ping Hsu, Wy Chan Lee

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Liver morphology and function were restudied after an interval of 11/2-2 years in 21 Chinese men with hepatitis B antigen (HBsAg). Antigenemia and mild liver histopathology disappeared in one individual who developed antibody to HBsAg (Anti-HBsAg). 20 subjects who were chronic carriers of HBsAg had mild histological abnormalities which were usually persistent and were more commonly lobular than portal. Particularly striking were focal necrosis, eosinophilic bodies, ground-glass cytoplasmic change, and, by electron microscopy, microtubular structures within cytoplasmic membranous cysternae. Interval development of chronic aggressive hepatitis was observed in only one subject. This study suggests that the great majority of HBsAg carriers have a good prognosis at least over a 11/2-2-year period, and that liver biopsy is most indicated in those with persistent liver function abnormalities.

Original languageEnglish (US)
Pages (from-to)366-369
Number of pages4
JournalThe American Journal of Digestive Diseases
Volume21
Issue number5
DOIs
StatePublished - May 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Serial liver biopsy observations in hepatitis B antigen carriers by light and electron microscopy'. Together they form a unique fingerprint.

  • Cite this