Sero-characterization of lipopolysaccharide from Burkholderia thailandensis

Omar Qazi, Joann L. Prior, Barbara M. Judy, Gregory C. Whitlock, G. Barrie Kitto, Alfredo Torres, D. Mark Estes, Katherine A. Brown

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Summary: We report the successful purification of lipopolysaccharide (LPS) from Burkholderia thailandensis, a Gram-negative bacterium, closely related to the highly pathogenic organisms B. pseudomallei and B. mallei. Burkholderia thailandensis LPS is shown to cross-react with rabbit and mouse sera obtained from inoculation with B. pseudomallei or B. mallei, respectively. These data suggest that B. thailandensis LPS shares similar structural features with LPS molecules from highly pathogenic Burkholderia species. This information may prove useful in ongoing efforts to develop novel vaccines and/or diagnostic reagents.

Original languageEnglish (US)
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume102
Issue numberSUPPL. 1
DOIs
StatePublished - Dec 2008

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Keywords

  • Burkholderia
  • Immune sera
  • Immunogenic
  • Lipopolysaccharide
  • SDS-PAGE
  • Virulence

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health

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