Serodiagnosis of the acquired immune deficiency syndrome by enzyme-linked immunosorbent assay compared to cellular immunologic parameters in African AIDS patients and controls

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Abstract

The sensitivity and specificity of an enzyme-linked immunosorbent assay (ELISA), absolute numbers of T-helper cells, and T-helper:T-suppressor cell ratios were compared in asymptomatic controls and IgG Western blot-confirmed patients with the acquired immune deficiency syndrome (AIDS) in Kinshasa, Zaire, between August 1984 and May 1985. Two hundred sixteen (97.7%) of 221 IgG Western blot-positive AIDS patients and 4 of 97 (4%) controls were ELISA-positive, 3 of whom were Western blot-positive. The sensitivity and specificity of the ELISA was 97.7% and 99.0%, respectively, compared to Western blot results. Detection of the human immune deficiency virus using absolute number of T-helper cells (3) was as sensitive (98.2%), but less specific (90.7%). A T-helper:T-suppressor ratio of

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ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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Francis, H. L., Mann, J., Colebunders, R. L., Ndongala, L., Mavunza-Mpaka, D., Bila, K., Curran, J., Piot, P., & Quinn, T. C. (1988). Serodiagnosis of the acquired immune deficiency syndrome by enzyme-linked immunosorbent assay compared to cellular immunologic parameters in African AIDS patients and controls. American Journal of Tropical Medicine and Hygiene, 38(3), 641-646.