Serodiagnosis of the acquired immune deficiency syndrome by enzyme-linked immunosorbent assay compared to cellular immunologic parameters in African AIDS patients and controls

H. L. Francis, J. Mann, R. L. Colebunders, L. Ndongala, D. Mavunza-Mpaka, K. Bila, J. Curran, P. Piot, T. C. Quinn

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The sensitivity and specificity of an enzyme-linked immunosorbent assay (ELISA), absolute numbers of T-helper cells, and T-helper:T-suppressor cell ratios were compared in asymptomatic controls and IgG Western blot-confirmed patients with the acquired immune deficiency syndrome (AIDS) in Kinshasa, Zaire, between August 1984 and May 1985. Two hundred sixteen (97.7%) of 221 IgG Western blot-positive AIDS patients and 4 of 97 (4%) controls were ELISA-positive, 3 of whom were Western blot-positive. The sensitivity and specificity of the ELISA was 97.7% and 99.0%, respectively, compared to Western blot results. Detection of the human immune deficiency virus using absolute number of T-helper cells (3) was as sensitive (98.2%), but less specific (90.7%). A T-helper:T-suppressor ratio of

Original languageEnglish (US)
Pages (from-to)641-646
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume38
Issue number3
StatePublished - 1988
Externally publishedYes

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Serologic Tests
Helper-Inducer T-Lymphocytes
Acquired Immunodeficiency Syndrome
Western Blotting
Enzyme-Linked Immunosorbent Assay
Immunoglobulin G
Democratic Republic of the Congo
Sensitivity and Specificity
Viruses

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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Serodiagnosis of the acquired immune deficiency syndrome by enzyme-linked immunosorbent assay compared to cellular immunologic parameters in African AIDS patients and controls. / Francis, H. L.; Mann, J.; Colebunders, R. L.; Ndongala, L.; Mavunza-Mpaka, D.; Bila, K.; Curran, J.; Piot, P.; Quinn, T. C.

In: American Journal of Tropical Medicine and Hygiene, Vol. 38, No. 3, 1988, p. 641-646.

Research output: Contribution to journalArticle

Francis, HL, Mann, J, Colebunders, RL, Ndongala, L, Mavunza-Mpaka, D, Bila, K, Curran, J, Piot, P & Quinn, TC 1988, 'Serodiagnosis of the acquired immune deficiency syndrome by enzyme-linked immunosorbent assay compared to cellular immunologic parameters in African AIDS patients and controls', American Journal of Tropical Medicine and Hygiene, vol. 38, no. 3, pp. 641-646.
Francis, H. L. ; Mann, J. ; Colebunders, R. L. ; Ndongala, L. ; Mavunza-Mpaka, D. ; Bila, K. ; Curran, J. ; Piot, P. ; Quinn, T. C. / Serodiagnosis of the acquired immune deficiency syndrome by enzyme-linked immunosorbent assay compared to cellular immunologic parameters in African AIDS patients and controls. In: American Journal of Tropical Medicine and Hygiene. 1988 ; Vol. 38, No. 3. pp. 641-646.
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AU - Mavunza-Mpaka, D.

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AU - Curran, J.

AU - Piot, P.

AU - Quinn, T. C.

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