Seroepidemiological Prevalence of Multiple Species of Filoviruses in Fruit Bats (Eidolon helvum) Migrating in Africa

Hirohito Ogawa; Hiroko Miyamoto; Eri Nakayama; Reiko Yoshida; Ichiro Nakamura; Hirofumi Sawa; Akihiro Ishii; Yuka Thomas; Emiko Nakagawa; Keita Matsuno; Masahiro Kajihara; Junki Maruyama; Naganori Nao; Mieko Muramatsu; Makoto Kuroda; Edgar Simulundu; Katendi Changula; Bernard Hang'Ombe; Boniface Namangala; Andrew Nambota; Jackson Katampi; Manabu Igarashi; Kimihito Ito; Heinz Feldmann; Chihiro Sugimoto; Ladslav Moonga; Aaron Mweene; Ayato Takada

doi:10.1093/infdis/jiv063

Seroepidemiological Prevalence of Multiple Species of Filoviruses in Fruit Bats (Eidolon helvum) Migrating in Africa

Hirohito Ogawa, Hiroko Miyamoto, Eri Nakayama, Reiko Yoshida, Ichiro Nakamura, Hirofumi Sawa, Akihiro Ishii, Yuka Thomas, Emiko Nakagawa, Keita Matsuno, Masahiro Kajihara, Junki Maruyama, Naganori Nao, Mieko Muramatsu, Makoto Kuroda, Edgar Simulundu, Katendi Changula, Bernard Hang'Ombe, Boniface Namangala, Andrew NambotaJackson Katampi, Manabu Igarashi, Kimihito Ito, Heinz Feldmann, Chihiro Sugimoto, Ladslav Moonga, Aaron Mweene, Ayato Takada

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

Fruit bats are suspected to be a natural reservoir of filoviruses, including Ebola and Marburg viruses. Using an enzyme-linked immunosorbent assay based on the viral glycoprotein antigens, we detected filovirus-specific immunoglobulin G antibodies in 71 of 748 serum samples collected from migratory fruit bats (Eidolon helvum) in Zambia during 2006-2013. Although antibodies to African filoviruses (eg, Zaire ebolavirus) were most prevalent, some serum samples showed distinct specificity for Reston ebolavirus, which that has thus far been found only in Asia. Interestingly, the transition of filovirus species causing outbreaks in Central and West Africa during 2005-2014 seemed to be synchronized with the change of the serologically dominant virus species in these bats. These data suggest the introduction of multiple species of filoviruses in the migratory bat population and point to the need for continued surveillance of filovirus infection of wild animals in sub-Saharan Africa, including hitherto nonendemic countries.

Original language	English (US)
Pages (from-to)	S101-S108
Journal	Journal of Infectious Diseases
Volume	212
DOIs	https://doi.org/10.1093/infdis/jiv063
State	Published - Oct 1 2015
Externally published	Yes

Keywords

Ebola virus
Marburg virus
Zambia
filovirus
fruit bat
specific antibody

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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Ogawa, H., Miyamoto, H., Nakayama, E., Yoshida, R., Nakamura, I., Sawa, H., Ishii, A., Thomas, Y., Nakagawa, E., Matsuno, K., Kajihara, M., Maruyama, J., Nao, N., Muramatsu, M., Kuroda, M., Simulundu, E., Changula, K., Hang'Ombe, B., Namangala, B., ... Takada, A. (2015). Seroepidemiological Prevalence of Multiple Species of Filoviruses in Fruit Bats (Eidolon helvum) Migrating in Africa. Journal of Infectious Diseases, 212, S101-S108. https://doi.org/10.1093/infdis/jiv063

Ogawa, H, Miyamoto, H, Nakayama, E, Yoshida, R, Nakamura, I, Sawa, H, Ishii, A, Thomas, Y, Nakagawa, E, Matsuno, K, Kajihara, M, Maruyama, J, Nao, N, Muramatsu, M, Kuroda, M, Simulundu, E, Changula, K, Hang'Ombe, B, Namangala, B, Nambota, A, Katampi, J, Igarashi, M, Ito, K, Feldmann, H, Sugimoto, C, Moonga, L, Mweene, A & Takada, A 2015, 'Seroepidemiological Prevalence of Multiple Species of Filoviruses in Fruit Bats (Eidolon helvum) Migrating in Africa', Journal of Infectious Diseases, vol. 212, pp. S101-S108. https://doi.org/10.1093/infdis/jiv063

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abstract = "Fruit bats are suspected to be a natural reservoir of filoviruses, including Ebola and Marburg viruses. Using an enzyme-linked immunosorbent assay based on the viral glycoprotein antigens, we detected filovirus-specific immunoglobulin G antibodies in 71 of 748 serum samples collected from migratory fruit bats (Eidolon helvum) in Zambia during 2006-2013. Although antibodies to African filoviruses (eg, Zaire ebolavirus) were most prevalent, some serum samples showed distinct specificity for Reston ebolavirus, which that has thus far been found only in Asia. Interestingly, the transition of filovirus species causing outbreaks in Central and West Africa during 2005-2014 seemed to be synchronized with the change of the serologically dominant virus species in these bats. These data suggest the introduction of multiple species of filoviruses in the migratory bat population and point to the need for continued surveillance of filovirus infection of wild animals in sub-Saharan Africa, including hitherto nonendemic countries.",

keywords = "Ebola virus, Marburg virus, Zambia, filovirus, fruit bat, specific antibody",

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AU - Ogawa, Hirohito

AU - Miyamoto, Hiroko

AU - Nakayama, Eri

AU - Yoshida, Reiko

AU - Nakamura, Ichiro

AU - Sawa, Hirofumi

AU - Ishii, Akihiro

AU - Thomas, Yuka

AU - Nakagawa, Emiko

AU - Matsuno, Keita

AU - Kajihara, Masahiro

AU - Maruyama, Junki

AU - Nao, Naganori

AU - Muramatsu, Mieko

AU - Kuroda, Makoto

AU - Simulundu, Edgar

AU - Changula, Katendi

AU - Hang'Ombe, Bernard

AU - Namangala, Boniface

AU - Nambota, Andrew

AU - Katampi, Jackson

AU - Igarashi, Manabu

AU - Ito, Kimihito

AU - Feldmann, Heinz

AU - Sugimoto, Chihiro

AU - Moonga, Ladslav

AU - Mweene, Aaron

AU - Takada, Ayato

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Fruit bats are suspected to be a natural reservoir of filoviruses, including Ebola and Marburg viruses. Using an enzyme-linked immunosorbent assay based on the viral glycoprotein antigens, we detected filovirus-specific immunoglobulin G antibodies in 71 of 748 serum samples collected from migratory fruit bats (Eidolon helvum) in Zambia during 2006-2013. Although antibodies to African filoviruses (eg, Zaire ebolavirus) were most prevalent, some serum samples showed distinct specificity for Reston ebolavirus, which that has thus far been found only in Asia. Interestingly, the transition of filovirus species causing outbreaks in Central and West Africa during 2005-2014 seemed to be synchronized with the change of the serologically dominant virus species in these bats. These data suggest the introduction of multiple species of filoviruses in the migratory bat population and point to the need for continued surveillance of filovirus infection of wild animals in sub-Saharan Africa, including hitherto nonendemic countries.

AB - Fruit bats are suspected to be a natural reservoir of filoviruses, including Ebola and Marburg viruses. Using an enzyme-linked immunosorbent assay based on the viral glycoprotein antigens, we detected filovirus-specific immunoglobulin G antibodies in 71 of 748 serum samples collected from migratory fruit bats (Eidolon helvum) in Zambia during 2006-2013. Although antibodies to African filoviruses (eg, Zaire ebolavirus) were most prevalent, some serum samples showed distinct specificity for Reston ebolavirus, which that has thus far been found only in Asia. Interestingly, the transition of filovirus species causing outbreaks in Central and West Africa during 2005-2014 seemed to be synchronized with the change of the serologically dominant virus species in these bats. These data suggest the introduction of multiple species of filoviruses in the migratory bat population and point to the need for continued surveillance of filovirus infection of wild animals in sub-Saharan Africa, including hitherto nonendemic countries.

KW - Ebola virus

KW - Marburg virus

KW - Zambia

KW - filovirus

KW - fruit bat

KW - specific antibody

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JF - Journal of Infectious Diseases

ER -

Seroepidemiological Prevalence of Multiple Species of Filoviruses in Fruit Bats (Eidolon helvum) Migrating in Africa

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