Seroepidemiological Prevalence of Multiple Species of Filoviruses in Fruit Bats (Eidolon helvum) Migrating in Africa

Hirohito Ogawa, Hiroko Miyamoto, Eri Nakayama, Reiko Yoshida, Ichiro Nakamura, Hirofumi Sawa, Akihiro Ishii, Yuka Thomas, Emiko Nakagawa, Keita Matsuno, Masahiro Kajihara, Junki Maruyama, Naganori Nao, Mieko Muramatsu, Makoto Kuroda, Edgar Simulundu, Katendi Changula, Bernard Hang'Ombe, Boniface Namangala, Andrew NambotaJackson Katampi, Manabu Igarashi, Kimihito Ito, Heinz Feldmann, Chihiro Sugimoto, Ladslav Moonga, Aaron Mweene, Ayato Takada

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Fruit bats are suspected to be a natural reservoir of filoviruses, including Ebola and Marburg viruses. Using an enzyme-linked immunosorbent assay based on the viral glycoprotein antigens, we detected filovirus-specific immunoglobulin G antibodies in 71 of 748 serum samples collected from migratory fruit bats (Eidolon helvum) in Zambia during 2006-2013. Although antibodies to African filoviruses (eg, Zaire ebolavirus) were most prevalent, some serum samples showed distinct specificity for Reston ebolavirus, which that has thus far been found only in Asia. Interestingly, the transition of filovirus species causing outbreaks in Central and West Africa during 2005-2014 seemed to be synchronized with the change of the serologically dominant virus species in these bats. These data suggest the introduction of multiple species of filoviruses in the migratory bat population and point to the need for continued surveillance of filovirus infection of wild animals in sub-Saharan Africa, including hitherto nonendemic countries.

Original languageEnglish (US)
Pages (from-to)S101-S108
JournalJournal of Infectious Diseases
Volume212
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Keywords

  • Ebola virus
  • filovirus
  • fruit bat
  • Marburg virus
  • specific antibody
  • Zambia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Ogawa, H., Miyamoto, H., Nakayama, E., Yoshida, R., Nakamura, I., Sawa, H., Ishii, A., Thomas, Y., Nakagawa, E., Matsuno, K., Kajihara, M., Maruyama, J., Nao, N., Muramatsu, M., Kuroda, M., Simulundu, E., Changula, K., Hang'Ombe, B., Namangala, B., ... Takada, A. (2015). Seroepidemiological Prevalence of Multiple Species of Filoviruses in Fruit Bats (Eidolon helvum) Migrating in Africa. Journal of Infectious Diseases, 212, S101-S108. https://doi.org/10.1093/infdis/jiv063