Seroepidemiological study of interepidemic Rift Valley fever virus infection among persons with intense ruminant exposure in Madagascar and Kenya

Gregory C. Gray, Benjamin D. Anderson, A. Desirée Labeaud, Jean Michel Heraud, Eric M. Fèvre, Soa Fy Andriamandimby, Elizabeth A.J. Cook, Saidi Dahir, William A. De Glanville, Gary L. Heil, Salah U. Khan, Samuel Muiruri, Marie Marie Olive, Lian F. Thomas, Hunter R. Merrill, Mary L.M. Merrill, Juergen A. Richt

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

In this cross-sectional seroepidemiological study we sought to examine the evidence for circulation of Rift Valley fever virus (RVFV) among herders in Madagascar and Kenya. From July 2010 to June 2012, we enrolled 459 herders and 98 controls (without ruminant exposures) and studied their sera (immunoglobulin G [IgG] and IgM through enzyme-linked immunosorbent assay [ELISA] and plaque reduction neutralization test [PRNT] assays) for evidence of previous RVFV infection. Overall, 59 (12.9%) of 459 herders and 7 (7.1%) of the 98 controls were positive by the IgG ELISA assay. Of the 59 ELISA-positive herders, 23 (38.9%) were confirmed by the PRNT assay (21 from eastern Kenya). Two of the 21 PRNT-positive study subjects also had elevated IgM antibodies against RVFV suggesting recent infection. Multivariate modeling in this study revealed that being seminomadic (odds ratio [OR] = 6.4, 95% confidence interval [CI] = 2.1-15.4) was most strongly associated with antibodies against RVFV. Although we cannot know when these infections occurred, it seems likely that some interepidemic RVFV infections are occurring among herders. As there are disincentives regarding reporting RVFVoutbreaks in livestock or wildlife, it may be prudent to conduct periodic, limited, active seroepidemiological surveillance for RVFV infections in herders, especially in eastern Kenya.

Original languageEnglish (US)
Pages (from-to)1364-1370
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume93
Issue number6
DOIs
StatePublished - Dec 2015
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Seroepidemiological study of interepidemic Rift Valley fever virus infection among persons with intense ruminant exposure in Madagascar and Kenya'. Together they form a unique fingerprint.

Cite this