@article{76345f803d7544deac2137ec62eaf14a,
title = "Serologic and genetic identification of peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern united states",
abstract = "An outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was etiologically linked to a newly recognized hantavirus. Knowledge that hantaviruses are maintained in rodent reservoirs stimulated a field and laboratory investigation of 1696 small mammals of 31 species. The most commonly captured rodent, the deer mouse (Peromyscus maniculatus), had the highest antibody prevalence (30%) to four hantavirus antigens. Antibody also was detected in 10 other species of rodent and in 1 species of rabbit. Reverse transcriptase-polymerase chain reaction (RT-PCR) products of hantavirus from rodent tissues were indistinguishable from those from human HPS patients. More than 96% of the seropositive P. maniculatus were positive by RT-PCR, suggesting chronic infection. Antibody prevalences were similar among P. maniculatus trapped from Arizona (33%), New Mexico (29%), and Colorado (29%). The numeric dominance of P. maniculatus, the high prevalence of antibody, and the RT-PCR findings implicate this species as the primary rodent reservoir for a new hantavirus in the southwestern United States.",
author = "Childs, {James E.} and Ksiazek, {Thomas G.} and Spiropoulou, {Christina F.} and Krebs, {John W.} and Sergey Morzunov and Maupin, {Gary O.} and Gage, {Kenneth L.} and Rollin, {Pierre E.} and John Sarisky and Enscore, {Russell E.} and Frey, {Jennifer K.} and Peters, {C. J.} and Nichol, {Stuart T.}",
note = "Funding Information: Received 27 October 1993; revised 12 January 1994. Presented in part: First International Congress of Vector Ecology. October 1993, San Diego (paper 60); 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, October 1993. New Orleans; and (sponsored by American Committee on Arbovirology) American Society of Tropical Medicine and Hygiene annual meeting. November 1993, Atlanta (paper S93). The opinions expressed here are those ofthe authors and do not necessarily reflect the views of the Indian Health Service. Grant support: US Department ofAgriculture Animal Molecular Biology National Research Initiative grant (90-37266-5473) through University of Nevada. Reno (C.F.S. and S.M.). Reprints or correspondence: Dr. James E. Childs. Viral & Rickettsial Zoonoses Branch, CDC, MS-G 13, 1600 Clifton Rd .• Atlanta, GA 30333.",
year = "1994",
month = jun,
doi = "10.1093/infdis/169.6.1271",
language = "English (US)",
volume = "169",
pages = "1271--1280",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",
}