Serologic evidence of hantaviral infections within small mammal communities of Baltimore, Maryland

Spatial and temporal patterns and host range

G. W. Korch, J. E. Childs, G. E. Glass, C. A. Rossi, James LeDuc

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Serologic evidence was used to investigate the spatial and temporal distribution and host range of hantaviruses in small mammal communities in Baltimore, MD. Immunofluorescent antibody (IFA) reactive to a Baltimore rat isolate of Seoul virus was detected in 44% of 404 Norway rats captured at 4 park or residential locations; 21% of 121 meadow voles captured at 4 park locations possessed significant IFA titers to Prospect Hill virus. Evidence from plaque neutralization assay of rodent sera suggested that Seoul virus and Prospect Hill virus circulated concurrently in voles and rats, respectively, at 1 park. No cross infection of virus between these primary reservoir species was observed, as determined by higher specific neutralizing antibody titers to the characteristic virus for each host species. Only 4% of 449 house mice and 1% of 94 white-footed mice captured at the same sites as the primary host species were seropositive to hantaviruses, despite extensive demonstrated overlap in time and space with the primary host species.

Original languageEnglish (US)
Pages (from-to)230-240
Number of pages11
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume41
Issue number2
StatePublished - 1989
Externally publishedYes

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Baltimore
Host Specificity
Mammals
Seoul virus
Hantavirus
Viruses
Arvicolinae
Infection
Peromyscus
Antibodies
Cross Infection
Neutralizing Antibodies
Rodentia
Serum

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Serologic evidence of hantaviral infections within small mammal communities of Baltimore, Maryland : Spatial and temporal patterns and host range. / Korch, G. W.; Childs, J. E.; Glass, G. E.; Rossi, C. A.; LeDuc, James.

In: American Journal of Tropical Medicine and Hygiene, Vol. 41, No. 2, 1989, p. 230-240.

Research output: Contribution to journalArticle

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