Serologic evidence of widespread everglades virus activity in dogs, Florida

Lark L. Coffey, Cynda Crawford, James Dee, Ryan Miller, Jerome Freier, Scott C. Weaver

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Everglades virus (EVEV), an alphavirus in the Venezuelan equine encephalitis complex, circulates among rodents and vector mosquitoes in Florida and occasionally infects humans. It causes febrile disease, sometimes accompanied by neurologic manifestations. Although previous surveys showed high seroprevalence in humans, EVEV infections may be underdiagnosed because the disease is not severe enough to warrant a clinic visit or the undifferentiated presentations complicate diagnosis. Documented EVEV activity, as recent as 1993, was limited to south Florida. Using dogs as sentinels, a serosurvey was conducted to evaluate whether EVEV circulated recently in Florida and whether EVEV's spatial distribution parallels that of the mosquito vector, Culex cedecei. Four percent of dog sera contained neutralizing EVEV antibodies, and many seropositive animals lived farther north than both recorded EVEV activity and the principal vector. These results indicate that EVEV is widespread in Florida and may be an important, unrecognized cause of human illness.

Original languageEnglish (US)
Pages (from-to)1873-1879
Number of pages7
JournalEmerging infectious diseases
Issue number12
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


Dive into the research topics of 'Serologic evidence of widespread everglades virus activity in dogs, Florida'. Together they form a unique fingerprint.

Cite this