Serologic study of the prevalence of rickettsiosis in Yucatan: Evidence for a prevalent spotted fever group rickettsiosis

Jorge E. Zavala-Velazquez, Jose Ruiz-Sosa, Ignacio Vado-Solis, Adrian N. Billings, David Walker

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Because of the discovery of a spotted fever group rickettsiosis with signs and symptoms similar to dengue fever in Yucatan, Mexico, immunofluorescence assay (IFA) serology was performed on sera from 390 persons selected from a representative geographic distribution of rural Yucatan to detect antibodies reactive with Rickettsia rickettsii, R. akari, a Thai strain (TT-118) that is most closely related to a rickettsia identified in Amblyomma cajennense ticks in southern Texas, and R. typhi. The IFA antibodies at titers ≥1:64 against R. akari were detected in 22 (5.6%) of the samples with the expected cross-reactivity against the other antigens of the spotted fever group. Immunoblotting with antigens of R. akari identified antibodies against antigens of spotted fever group lipopolysaccharides and not against rickettsial outer membrane proteins A and B, which contain the species-specific epitopes. A rickettsiosis most likely caused by a relative of R. akari appears to be both prevalent and widely distributed geographically in Yucatan.

Original languageEnglish (US)
Pages (from-to)405-408
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume61
Issue number3
StatePublished - Sep 1999

Fingerprint

Fever
Cross-Sectional Studies
Antigens
Fluorescent Antibody Technique
Antibodies
Rickettsia rickettsii
Rickettsia
Dengue
Ticks
Serology
Mexico
Immunoblotting
Signs and Symptoms
Lipopolysaccharides
Epitopes
Serum
IgA receptor
Rickettsia rOmpA

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Serologic study of the prevalence of rickettsiosis in Yucatan : Evidence for a prevalent spotted fever group rickettsiosis. / Zavala-Velazquez, Jorge E.; Ruiz-Sosa, Jose; Vado-Solis, Ignacio; Billings, Adrian N.; Walker, David.

In: American Journal of Tropical Medicine and Hygiene, Vol. 61, No. 3, 09.1999, p. 405-408.

Research output: Contribution to journalArticle

Zavala-Velazquez, Jorge E. ; Ruiz-Sosa, Jose ; Vado-Solis, Ignacio ; Billings, Adrian N. ; Walker, David. / Serologic study of the prevalence of rickettsiosis in Yucatan : Evidence for a prevalent spotted fever group rickettsiosis. In: American Journal of Tropical Medicine and Hygiene. 1999 ; Vol. 61, No. 3. pp. 405-408.
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