Seroprevalence of Kaposi's sarcoma-associated herpesvirus infection among blood donors from Texas

Jacques Baillargeon, Jian Hong Deng, Evelyn Hettler, Chantal Harrison, James J. Grady, Laura G. Korte, James Alexander, Eduardo Montalvo, Hal B. Jenson, Shou Jiang Gao

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

PURPOSE: Kaposi's sarcoma-associated herpesvirus (KSHV), a gammaherpesvirus recently discovered among AIDS patients with Kaposi's sarcoma, is a potential candidate for screening in blood and plasma donors. While a number of studies have assessed KSHV infection among U.S. blood donors, larger-scale population-based studies would be necessary to develop more refined estimates of the magnitude and variation of KSHV infection across different geographic regions of the U.S. blood supply. The goal of the present study, therefore, was to determine the seroprevalence of KSHV infection and to assess demographic correlates of KSHV infection among south Texas blood donors. METHODS: KSHV infection was determined using specific serologic assays that measure antibodies to KSHV latent and lytic antigens. RESULTS: The overall seroprevalence of KSHV in Texas blood donors (15.0%) is substantially higher than previously reported among blood donor and general population samples in the United States. This high rate of KSHV infection persisted across most of the sociodemographic subgroups under study but was particularly elevated among participants with less than a high school education. The infection rate also increased linearly with age. CONCLUSIONS: The elevated infection rate reported in the present study suggests that screening methods to detect KSHV infection in blood donors should be considered. In view of the etiologic role of KSHV for several malignancies, it would be important for future studies to directly assess the risk of KSHV transmission via blood transfusion.

Original languageEnglish (US)
Pages (from-to)512-518
Number of pages7
JournalAnnals of Epidemiology
Volume11
Issue number7
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Herpesviridae Infections
Human Herpesvirus 8
Seroepidemiologic Studies
Blood Donors
Kaposi's Sarcoma
Infection
Blood Transfusion
Population
Acquired Immunodeficiency Syndrome

Keywords

  • Blood donors
  • KS
  • KSHV
  • Seroprevalence

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Seroprevalence of Kaposi's sarcoma-associated herpesvirus infection among blood donors from Texas. / Baillargeon, Jacques; Deng, Jian Hong; Hettler, Evelyn; Harrison, Chantal; Grady, James J.; Korte, Laura G.; Alexander, James; Montalvo, Eduardo; Jenson, Hal B.; Gao, Shou Jiang.

In: Annals of Epidemiology, Vol. 11, No. 7, 2001, p. 512-518.

Research output: Contribution to journalArticle

Baillargeon, J, Deng, JH, Hettler, E, Harrison, C, Grady, JJ, Korte, LG, Alexander, J, Montalvo, E, Jenson, HB & Gao, SJ 2001, 'Seroprevalence of Kaposi's sarcoma-associated herpesvirus infection among blood donors from Texas', Annals of Epidemiology, vol. 11, no. 7, pp. 512-518. https://doi.org/10.1016/S1047-2797(01)00242-3
Baillargeon, Jacques ; Deng, Jian Hong ; Hettler, Evelyn ; Harrison, Chantal ; Grady, James J. ; Korte, Laura G. ; Alexander, James ; Montalvo, Eduardo ; Jenson, Hal B. ; Gao, Shou Jiang. / Seroprevalence of Kaposi's sarcoma-associated herpesvirus infection among blood donors from Texas. In: Annals of Epidemiology. 2001 ; Vol. 11, No. 7. pp. 512-518.
@article{dd5e073958ef4cb18cef1feff9c6baf0,
title = "Seroprevalence of Kaposi's sarcoma-associated herpesvirus infection among blood donors from Texas",
abstract = "PURPOSE: Kaposi's sarcoma-associated herpesvirus (KSHV), a gammaherpesvirus recently discovered among AIDS patients with Kaposi's sarcoma, is a potential candidate for screening in blood and plasma donors. While a number of studies have assessed KSHV infection among U.S. blood donors, larger-scale population-based studies would be necessary to develop more refined estimates of the magnitude and variation of KSHV infection across different geographic regions of the U.S. blood supply. The goal of the present study, therefore, was to determine the seroprevalence of KSHV infection and to assess demographic correlates of KSHV infection among south Texas blood donors. METHODS: KSHV infection was determined using specific serologic assays that measure antibodies to KSHV latent and lytic antigens. RESULTS: The overall seroprevalence of KSHV in Texas blood donors (15.0{\%}) is substantially higher than previously reported among blood donor and general population samples in the United States. This high rate of KSHV infection persisted across most of the sociodemographic subgroups under study but was particularly elevated among participants with less than a high school education. The infection rate also increased linearly with age. CONCLUSIONS: The elevated infection rate reported in the present study suggests that screening methods to detect KSHV infection in blood donors should be considered. In view of the etiologic role of KSHV for several malignancies, it would be important for future studies to directly assess the risk of KSHV transmission via blood transfusion.",
keywords = "Blood donors, KS, KSHV, Seroprevalence",
author = "Jacques Baillargeon and Deng, {Jian Hong} and Evelyn Hettler and Chantal Harrison and Grady, {James J.} and Korte, {Laura G.} and James Alexander and Eduardo Montalvo and Jenson, {Hal B.} and Gao, {Shou Jiang}",
year = "2001",
doi = "10.1016/S1047-2797(01)00242-3",
language = "English (US)",
volume = "11",
pages = "512--518",
journal = "Annals of Epidemiology",
issn = "1047-2797",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Seroprevalence of Kaposi's sarcoma-associated herpesvirus infection among blood donors from Texas

AU - Baillargeon, Jacques

AU - Deng, Jian Hong

AU - Hettler, Evelyn

AU - Harrison, Chantal

AU - Grady, James J.

AU - Korte, Laura G.

AU - Alexander, James

AU - Montalvo, Eduardo

AU - Jenson, Hal B.

AU - Gao, Shou Jiang

PY - 2001

Y1 - 2001

N2 - PURPOSE: Kaposi's sarcoma-associated herpesvirus (KSHV), a gammaherpesvirus recently discovered among AIDS patients with Kaposi's sarcoma, is a potential candidate for screening in blood and plasma donors. While a number of studies have assessed KSHV infection among U.S. blood donors, larger-scale population-based studies would be necessary to develop more refined estimates of the magnitude and variation of KSHV infection across different geographic regions of the U.S. blood supply. The goal of the present study, therefore, was to determine the seroprevalence of KSHV infection and to assess demographic correlates of KSHV infection among south Texas blood donors. METHODS: KSHV infection was determined using specific serologic assays that measure antibodies to KSHV latent and lytic antigens. RESULTS: The overall seroprevalence of KSHV in Texas blood donors (15.0%) is substantially higher than previously reported among blood donor and general population samples in the United States. This high rate of KSHV infection persisted across most of the sociodemographic subgroups under study but was particularly elevated among participants with less than a high school education. The infection rate also increased linearly with age. CONCLUSIONS: The elevated infection rate reported in the present study suggests that screening methods to detect KSHV infection in blood donors should be considered. In view of the etiologic role of KSHV for several malignancies, it would be important for future studies to directly assess the risk of KSHV transmission via blood transfusion.

AB - PURPOSE: Kaposi's sarcoma-associated herpesvirus (KSHV), a gammaherpesvirus recently discovered among AIDS patients with Kaposi's sarcoma, is a potential candidate for screening in blood and plasma donors. While a number of studies have assessed KSHV infection among U.S. blood donors, larger-scale population-based studies would be necessary to develop more refined estimates of the magnitude and variation of KSHV infection across different geographic regions of the U.S. blood supply. The goal of the present study, therefore, was to determine the seroprevalence of KSHV infection and to assess demographic correlates of KSHV infection among south Texas blood donors. METHODS: KSHV infection was determined using specific serologic assays that measure antibodies to KSHV latent and lytic antigens. RESULTS: The overall seroprevalence of KSHV in Texas blood donors (15.0%) is substantially higher than previously reported among blood donor and general population samples in the United States. This high rate of KSHV infection persisted across most of the sociodemographic subgroups under study but was particularly elevated among participants with less than a high school education. The infection rate also increased linearly with age. CONCLUSIONS: The elevated infection rate reported in the present study suggests that screening methods to detect KSHV infection in blood donors should be considered. In view of the etiologic role of KSHV for several malignancies, it would be important for future studies to directly assess the risk of KSHV transmission via blood transfusion.

KW - Blood donors

KW - KS

KW - KSHV

KW - Seroprevalence

UR - http://www.scopus.com/inward/record.url?scp=0034841485&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034841485&partnerID=8YFLogxK

U2 - 10.1016/S1047-2797(01)00242-3

DO - 10.1016/S1047-2797(01)00242-3

M3 - Article

VL - 11

SP - 512

EP - 518

JO - Annals of Epidemiology

JF - Annals of Epidemiology

SN - 1047-2797

IS - 7

ER -