Seroprevalence of neutralizing antibodies against dengue virus in two localities in the state of Morelos, Mexico

Irma Y. Amaya-Larios, Ruth Aralí Martínez-Vega, Sandra V. Mayer, Marisol Galeana-Hernández, Andreu Comas-García, Karla J. Sepúlveda-Salinas, Jorge A. Falcón-Lezama, Nikos Vasilakis, José Ramos-Castañeda

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Humoral immune response against dengue virus (DENV) is an important component in dengue-endemic transmission. We conducted a cross-sectional nested cohort study to determine the seroprevalence and frequency of neutralizing antibodies against DENV serotypes in two endemic localities in the state of Morelos, Mexico. The cohort participants (N = 1,196) were screened to determine previous exposure to DENV. Overall seroprevalence was 76.6% (95% confidence interval [95% CI] = 73.6-79.2), and prevalence of neutralizing antibodies in the 5- to 9-year-old group was 82.5% (95% CI = 67.2-92.7), 45% (95% CI = 29.3-61.5), and 65% (95% CI = 48.3-79.4) for DENV-1, DENV-2, and DENV-3, respectively. For participants older than 10 years, the observed seroprevalence was above 60% for each serotype, except DENV-4 in the 10- to 25-year-old group (42.9%); 81% of humoral responses were multitypic. The outcomes of our study contribute to understanding the immune component of dengue transmission and provide focal information for the evaluation of vaccine candidates under development.

Original languageEnglish (US)
Pages (from-to)1057-1065
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume91
Issue number5
DOIs
StatePublished - Nov 1 2014

Fingerprint

Dengue Virus
Seroepidemiologic Studies
Mexico
Neutralizing Antibodies
Confidence Intervals
Dengue
Humoral Immunity
Cohort Studies
Vaccines
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Amaya-Larios, I. Y., Martínez-Vega, R. A., Mayer, S. V., Galeana-Hernández, M., Comas-García, A., Sepúlveda-Salinas, K. J., ... Ramos-Castañeda, J. (2014). Seroprevalence of neutralizing antibodies against dengue virus in two localities in the state of Morelos, Mexico. American Journal of Tropical Medicine and Hygiene, 91(5), 1057-1065. https://doi.org/10.4269/ajtmh.14-0145

Seroprevalence of neutralizing antibodies against dengue virus in two localities in the state of Morelos, Mexico. / Amaya-Larios, Irma Y.; Martínez-Vega, Ruth Aralí; Mayer, Sandra V.; Galeana-Hernández, Marisol; Comas-García, Andreu; Sepúlveda-Salinas, Karla J.; Falcón-Lezama, Jorge A.; Vasilakis, Nikos; Ramos-Castañeda, José.

In: American Journal of Tropical Medicine and Hygiene, Vol. 91, No. 5, 01.11.2014, p. 1057-1065.

Research output: Contribution to journalArticle

Amaya-Larios, IY, Martínez-Vega, RA, Mayer, SV, Galeana-Hernández, M, Comas-García, A, Sepúlveda-Salinas, KJ, Falcón-Lezama, JA, Vasilakis, N & Ramos-Castañeda, J 2014, 'Seroprevalence of neutralizing antibodies against dengue virus in two localities in the state of Morelos, Mexico', American Journal of Tropical Medicine and Hygiene, vol. 91, no. 5, pp. 1057-1065. https://doi.org/10.4269/ajtmh.14-0145
Amaya-Larios IY, Martínez-Vega RA, Mayer SV, Galeana-Hernández M, Comas-García A, Sepúlveda-Salinas KJ et al. Seroprevalence of neutralizing antibodies against dengue virus in two localities in the state of Morelos, Mexico. American Journal of Tropical Medicine and Hygiene. 2014 Nov 1;91(5):1057-1065. https://doi.org/10.4269/ajtmh.14-0145
Amaya-Larios, Irma Y. ; Martínez-Vega, Ruth Aralí ; Mayer, Sandra V. ; Galeana-Hernández, Marisol ; Comas-García, Andreu ; Sepúlveda-Salinas, Karla J. ; Falcón-Lezama, Jorge A. ; Vasilakis, Nikos ; Ramos-Castañeda, José. / Seroprevalence of neutralizing antibodies against dengue virus in two localities in the state of Morelos, Mexico. In: American Journal of Tropical Medicine and Hygiene. 2014 ; Vol. 91, No. 5. pp. 1057-1065.
@article{9001978b5d3b44608bba285e88b14059,
title = "Seroprevalence of neutralizing antibodies against dengue virus in two localities in the state of Morelos, Mexico",
abstract = "Humoral immune response against dengue virus (DENV) is an important component in dengue-endemic transmission. We conducted a cross-sectional nested cohort study to determine the seroprevalence and frequency of neutralizing antibodies against DENV serotypes in two endemic localities in the state of Morelos, Mexico. The cohort participants (N = 1,196) were screened to determine previous exposure to DENV. Overall seroprevalence was 76.6{\%} (95{\%} confidence interval [95{\%} CI] = 73.6-79.2), and prevalence of neutralizing antibodies in the 5- to 9-year-old group was 82.5{\%} (95{\%} CI = 67.2-92.7), 45{\%} (95{\%} CI = 29.3-61.5), and 65{\%} (95{\%} CI = 48.3-79.4) for DENV-1, DENV-2, and DENV-3, respectively. For participants older than 10 years, the observed seroprevalence was above 60{\%} for each serotype, except DENV-4 in the 10- to 25-year-old group (42.9{\%}); 81{\%} of humoral responses were multitypic. The outcomes of our study contribute to understanding the immune component of dengue transmission and provide focal information for the evaluation of vaccine candidates under development.",
author = "Amaya-Larios, {Irma Y.} and Mart{\'i}nez-Vega, {Ruth Aral{\'i}} and Mayer, {Sandra V.} and Marisol Galeana-Hern{\'a}ndez and Andreu Comas-Garc{\'i}a and Sep{\'u}lveda-Salinas, {Karla J.} and Falc{\'o}n-Lezama, {Jorge A.} and Nikos Vasilakis and Jos{\'e} Ramos-Casta{\~n}eda",
year = "2014",
month = "11",
day = "1",
doi = "10.4269/ajtmh.14-0145",
language = "English (US)",
volume = "91",
pages = "1057--1065",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "5",

}

TY - JOUR

T1 - Seroprevalence of neutralizing antibodies against dengue virus in two localities in the state of Morelos, Mexico

AU - Amaya-Larios, Irma Y.

AU - Martínez-Vega, Ruth Aralí

AU - Mayer, Sandra V.

AU - Galeana-Hernández, Marisol

AU - Comas-García, Andreu

AU - Sepúlveda-Salinas, Karla J.

AU - Falcón-Lezama, Jorge A.

AU - Vasilakis, Nikos

AU - Ramos-Castañeda, José

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Humoral immune response against dengue virus (DENV) is an important component in dengue-endemic transmission. We conducted a cross-sectional nested cohort study to determine the seroprevalence and frequency of neutralizing antibodies against DENV serotypes in two endemic localities in the state of Morelos, Mexico. The cohort participants (N = 1,196) were screened to determine previous exposure to DENV. Overall seroprevalence was 76.6% (95% confidence interval [95% CI] = 73.6-79.2), and prevalence of neutralizing antibodies in the 5- to 9-year-old group was 82.5% (95% CI = 67.2-92.7), 45% (95% CI = 29.3-61.5), and 65% (95% CI = 48.3-79.4) for DENV-1, DENV-2, and DENV-3, respectively. For participants older than 10 years, the observed seroprevalence was above 60% for each serotype, except DENV-4 in the 10- to 25-year-old group (42.9%); 81% of humoral responses were multitypic. The outcomes of our study contribute to understanding the immune component of dengue transmission and provide focal information for the evaluation of vaccine candidates under development.

AB - Humoral immune response against dengue virus (DENV) is an important component in dengue-endemic transmission. We conducted a cross-sectional nested cohort study to determine the seroprevalence and frequency of neutralizing antibodies against DENV serotypes in two endemic localities in the state of Morelos, Mexico. The cohort participants (N = 1,196) were screened to determine previous exposure to DENV. Overall seroprevalence was 76.6% (95% confidence interval [95% CI] = 73.6-79.2), and prevalence of neutralizing antibodies in the 5- to 9-year-old group was 82.5% (95% CI = 67.2-92.7), 45% (95% CI = 29.3-61.5), and 65% (95% CI = 48.3-79.4) for DENV-1, DENV-2, and DENV-3, respectively. For participants older than 10 years, the observed seroprevalence was above 60% for each serotype, except DENV-4 in the 10- to 25-year-old group (42.9%); 81% of humoral responses were multitypic. The outcomes of our study contribute to understanding the immune component of dengue transmission and provide focal information for the evaluation of vaccine candidates under development.

UR - http://www.scopus.com/inward/record.url?scp=84910647990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84910647990&partnerID=8YFLogxK

U2 - 10.4269/ajtmh.14-0145

DO - 10.4269/ajtmh.14-0145

M3 - Article

C2 - 25294613

AN - SCOPUS:84910647990

VL - 91

SP - 1057

EP - 1065

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 5

ER -