Serotonin2C receptors in the ventral pallidum regulate motor function in rats

Steven M. Graves, Annika A. Viskniskki, Kathryn Cunningham, T. Celeste Napier

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The ventral pallidum is a limbic brain region that regulates motor function. This region is extensively innervated by serotoninergic neurons from the dorsal raphe nucleus. Serotonergic receptors, including the 5-HT 2C receptor subtype, are located in the ventral pallidum. However, little is known regarding the behavioral consequences of serotonergic transmission in the ventral pallidum, and the role of 5-HT2C receptors has not been studied. To address this paucity, we measured the motoric consequences of injections of 0.33-10 ng of the 5-HT2C receptor agonist MK 212 into the ventral pallidum of adult male Sprague-Dawley rats. We determined that locomotor activity was attenuated by 6.6 ng MK 212, and rearing was attenuated by both 1 and 6.6 ng. The motor suppressant effects of MK 212 were lost at the higher dose of 10 ng, likely reflecting a loss of selectivity of this ligand. These findings indicate negative regulation of motor function by 5-HT2C receptors in the ventral pallidum.

Original languageEnglish (US)
Pages (from-to)605-608
Number of pages4
JournalNeuroReport
Volume24
Issue number11
DOIs
StatePublished - Aug 7 2013

Fingerprint

Receptor, Serotonin, 5-HT2C
Serotonin 5-HT2 Receptor Agonists
Serotonergic Neurons
Locomotion
Sprague Dawley Rats
Basal Forebrain
Ligands
Injections
Brain
6-chloro-2-(1-piperazinyl)pyrazine

Keywords

  • 5-HT receptor
  • MK 212
  • motor activity
  • serotonin
  • ventral pallidum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Serotonin2C receptors in the ventral pallidum regulate motor function in rats. / Graves, Steven M.; Viskniskki, Annika A.; Cunningham, Kathryn; Celeste Napier, T.

In: NeuroReport, Vol. 24, No. 11, 07.08.2013, p. 605-608.

Research output: Contribution to journalArticle

Graves, Steven M. ; Viskniskki, Annika A. ; Cunningham, Kathryn ; Celeste Napier, T. / Serotonin2C receptors in the ventral pallidum regulate motor function in rats. In: NeuroReport. 2013 ; Vol. 24, No. 11. pp. 605-608.
@article{8e64eacc33494584a167fd0705fbfb62,
title = "Serotonin2C receptors in the ventral pallidum regulate motor function in rats",
abstract = "The ventral pallidum is a limbic brain region that regulates motor function. This region is extensively innervated by serotoninergic neurons from the dorsal raphe nucleus. Serotonergic receptors, including the 5-HT 2C receptor subtype, are located in the ventral pallidum. However, little is known regarding the behavioral consequences of serotonergic transmission in the ventral pallidum, and the role of 5-HT2C receptors has not been studied. To address this paucity, we measured the motoric consequences of injections of 0.33-10 ng of the 5-HT2C receptor agonist MK 212 into the ventral pallidum of adult male Sprague-Dawley rats. We determined that locomotor activity was attenuated by 6.6 ng MK 212, and rearing was attenuated by both 1 and 6.6 ng. The motor suppressant effects of MK 212 were lost at the higher dose of 10 ng, likely reflecting a loss of selectivity of this ligand. These findings indicate negative regulation of motor function by 5-HT2C receptors in the ventral pallidum.",
keywords = "5-HT receptor, MK 212, motor activity, serotonin, ventral pallidum",
author = "Graves, {Steven M.} and Viskniskki, {Annika A.} and Kathryn Cunningham and {Celeste Napier}, T.",
year = "2013",
month = "8",
day = "7",
doi = "10.1097/WNR.0b013e3283630af5",
language = "English (US)",
volume = "24",
pages = "605--608",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Serotonin2C receptors in the ventral pallidum regulate motor function in rats

AU - Graves, Steven M.

AU - Viskniskki, Annika A.

AU - Cunningham, Kathryn

AU - Celeste Napier, T.

PY - 2013/8/7

Y1 - 2013/8/7

N2 - The ventral pallidum is a limbic brain region that regulates motor function. This region is extensively innervated by serotoninergic neurons from the dorsal raphe nucleus. Serotonergic receptors, including the 5-HT 2C receptor subtype, are located in the ventral pallidum. However, little is known regarding the behavioral consequences of serotonergic transmission in the ventral pallidum, and the role of 5-HT2C receptors has not been studied. To address this paucity, we measured the motoric consequences of injections of 0.33-10 ng of the 5-HT2C receptor agonist MK 212 into the ventral pallidum of adult male Sprague-Dawley rats. We determined that locomotor activity was attenuated by 6.6 ng MK 212, and rearing was attenuated by both 1 and 6.6 ng. The motor suppressant effects of MK 212 were lost at the higher dose of 10 ng, likely reflecting a loss of selectivity of this ligand. These findings indicate negative regulation of motor function by 5-HT2C receptors in the ventral pallidum.

AB - The ventral pallidum is a limbic brain region that regulates motor function. This region is extensively innervated by serotoninergic neurons from the dorsal raphe nucleus. Serotonergic receptors, including the 5-HT 2C receptor subtype, are located in the ventral pallidum. However, little is known regarding the behavioral consequences of serotonergic transmission in the ventral pallidum, and the role of 5-HT2C receptors has not been studied. To address this paucity, we measured the motoric consequences of injections of 0.33-10 ng of the 5-HT2C receptor agonist MK 212 into the ventral pallidum of adult male Sprague-Dawley rats. We determined that locomotor activity was attenuated by 6.6 ng MK 212, and rearing was attenuated by both 1 and 6.6 ng. The motor suppressant effects of MK 212 were lost at the higher dose of 10 ng, likely reflecting a loss of selectivity of this ligand. These findings indicate negative regulation of motor function by 5-HT2C receptors in the ventral pallidum.

KW - 5-HT receptor

KW - MK 212

KW - motor activity

KW - serotonin

KW - ventral pallidum

UR - http://www.scopus.com/inward/record.url?scp=84879907646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879907646&partnerID=8YFLogxK

U2 - 10.1097/WNR.0b013e3283630af5

DO - 10.1097/WNR.0b013e3283630af5

M3 - Article

VL - 24

SP - 605

EP - 608

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 11

ER -