Serotonin2C receptors in the ventral pallidum regulate motor function in rats

Steven M. Graves, Annika A. Viskniskki, Kathryn A. Cunningham, T. Celeste Napier

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The ventral pallidum is a limbic brain region that regulates motor function. This region is extensively innervated by serotoninergic neurons from the dorsal raphe nucleus. Serotonergic receptors, including the 5-HT 2C receptor subtype, are located in the ventral pallidum. However, little is known regarding the behavioral consequences of serotonergic transmission in the ventral pallidum, and the role of 5-HT2C receptors has not been studied. To address this paucity, we measured the motoric consequences of injections of 0.33-10 ng of the 5-HT2C receptor agonist MK 212 into the ventral pallidum of adult male Sprague-Dawley rats. We determined that locomotor activity was attenuated by 6.6 ng MK 212, and rearing was attenuated by both 1 and 6.6 ng. The motor suppressant effects of MK 212 were lost at the higher dose of 10 ng, likely reflecting a loss of selectivity of this ligand. These findings indicate negative regulation of motor function by 5-HT2C receptors in the ventral pallidum.

Original languageEnglish (US)
Pages (from-to)605-608
Number of pages4
JournalNeuroReport
Volume24
Issue number11
DOIs
StatePublished - Aug 7 2013

Keywords

  • 5-HT receptor
  • MK 212
  • motor activity
  • serotonin
  • ventral pallidum

ASJC Scopus subject areas

  • Neuroscience(all)

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