Abstract
Environmental cues can become classically conditioned to cocaine exposure and are known to contribute to drug craving and relapse in addicts. The 5-HT2C receptor (5-HT2CR) has been shown to control the behavioral effects of acute cocaine administration and, in the present study, we investigated the role of this receptor in the expression of cocaine-induced conditioned hyperactivity. Rats received repeated pairings of a distinct test environment with either saline or cocaine (15 mg/kg, i.p.) for 7 days. In a drug-free test 2 days after the last pairing, expression of conditioned hyperactivity was seen in the rats previously exposed to cocaine in the test environment. The 5-HT2CR agonist MK 212 (0.0625-0.5 mg/kg, i.p., 5 min before test) significantly decreased, while the 5-HT2CR antagonist SB 242084 (0.5-1 mg/kg, i.p. 30 min prior to test) enhanced, expression of cocaine-induced conditioned hyperactivity. The effective doses of MK 212 and SB 242084 did not alter basal activity on the test session. These results suggest that the 5-HT2CR controls expression of cocaine-induced conditioned hyperactivity and suggest that such ligands may be useful in preventing relapse and promoting abstinence in cocaine-dependent individuals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 275-282 |
| Number of pages | 8 |
| Journal | Drug and Alcohol Dependence |
| Volume | 81 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 28 2006 |
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Keywords
- 5-HTR
- Cocaine
- Conditioned hyperactivity
- MK 212
- Rat
- SB 242084
ASJC Scopus subject areas
- Medicine(all)
- Behavioral Neuroscience
- Toxicology
- Health(social science)
Cite this
Serotonin2C receptors (5-HT2CR) control expression of cocaine-induced conditioned hyperactivity. / Liu, Shijing; Cunningham, Kathryn.
In: Drug and Alcohol Dependence, Vol. 81, No. 3, 28.02.2006, p. 275-282.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serotonin2C receptors (5-HT2CR) control expression of cocaine-induced conditioned hyperactivity
AU - Liu, Shijing
AU - Cunningham, Kathryn
PY - 2006/2/28
Y1 - 2006/2/28
N2 - Environmental cues can become classically conditioned to cocaine exposure and are known to contribute to drug craving and relapse in addicts. The 5-HT2C receptor (5-HT2CR) has been shown to control the behavioral effects of acute cocaine administration and, in the present study, we investigated the role of this receptor in the expression of cocaine-induced conditioned hyperactivity. Rats received repeated pairings of a distinct test environment with either saline or cocaine (15 mg/kg, i.p.) for 7 days. In a drug-free test 2 days after the last pairing, expression of conditioned hyperactivity was seen in the rats previously exposed to cocaine in the test environment. The 5-HT2CR agonist MK 212 (0.0625-0.5 mg/kg, i.p., 5 min before test) significantly decreased, while the 5-HT2CR antagonist SB 242084 (0.5-1 mg/kg, i.p. 30 min prior to test) enhanced, expression of cocaine-induced conditioned hyperactivity. The effective doses of MK 212 and SB 242084 did not alter basal activity on the test session. These results suggest that the 5-HT2CR controls expression of cocaine-induced conditioned hyperactivity and suggest that such ligands may be useful in preventing relapse and promoting abstinence in cocaine-dependent individuals.
AB - Environmental cues can become classically conditioned to cocaine exposure and are known to contribute to drug craving and relapse in addicts. The 5-HT2C receptor (5-HT2CR) has been shown to control the behavioral effects of acute cocaine administration and, in the present study, we investigated the role of this receptor in the expression of cocaine-induced conditioned hyperactivity. Rats received repeated pairings of a distinct test environment with either saline or cocaine (15 mg/kg, i.p.) for 7 days. In a drug-free test 2 days after the last pairing, expression of conditioned hyperactivity was seen in the rats previously exposed to cocaine in the test environment. The 5-HT2CR agonist MK 212 (0.0625-0.5 mg/kg, i.p., 5 min before test) significantly decreased, while the 5-HT2CR antagonist SB 242084 (0.5-1 mg/kg, i.p. 30 min prior to test) enhanced, expression of cocaine-induced conditioned hyperactivity. The effective doses of MK 212 and SB 242084 did not alter basal activity on the test session. These results suggest that the 5-HT2CR controls expression of cocaine-induced conditioned hyperactivity and suggest that such ligands may be useful in preventing relapse and promoting abstinence in cocaine-dependent individuals.
KW - 5-HTR
KW - Cocaine
KW - Conditioned hyperactivity
KW - MK 212
KW - Rat
KW - SB 242084
UR - http://www.scopus.com/inward/record.url?scp=31444452350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=31444452350&partnerID=8YFLogxK
U2 - 10.1016/j.drugalcdep.2005.07.007
DO - 10.1016/j.drugalcdep.2005.07.007
M3 - Article
C2 - 16146672
AN - SCOPUS:31444452350
VL - 81
SP - 275
EP - 282
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
SN - 0376-8716
IS - 3
ER -