Serum adiponectin, resistin, and circulating soluble receptor for advanced glycation end products in colectomy patients

Theodor Asgeirsson, Sen Zhang, Sok Kean Khoo, James H. Resau, Nadav Dujovny, Anthony J. Senagore

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim. Surgical trauma and associated complications are frequently related to physiological stress during colectomy. This study evaluated the response of adiponectin, resistin, and circulating soluble receptor for advanced glycation end products (sRAGE) in colectomy patients with or without an enhanced recovery protocol. Method. Serum samples were collected from 44 colectomy patients at 3 timframes. The surgical procedures were laparoscopic (LAP), hand-assisted laparoscopic (HALS), or open colectomy (OPEN). Adiponectin, resistin, and sRAGE levels were determined by ELISA. Repeated measures ANOVA was applied and P values <0.05 were considered significant. Results. A total of 132 (44 × 3) sera were used for analysis. Levels of adiponectin was significantly decreased between PREOP and POD3 (P <0.001). Conversely, concentrations of resistin significantly increased from PREOP to POD1 and returned to baseline value by POD3 (P <0.001). Serum sRAGE levels were significantly higher in LAP in comparison with HALS (P = 0.004) and OPEN (P <0.001). sRAGE levels were significantly higher in sera of patients that underwent ERP (P <0.001). Conclusions. Serum adiponectin, resistin, and sRAGE have the potential to develop into a panel of stress markers. Higher sRAGE levels in sera of LAP and ERP patients may be indicative of a protective and syngeristic role for colectomy recovery.

Original languageEnglish (US)
Article number916807
JournalMediators of Inflammation
Volume2011
DOIs
StatePublished - 2011
Externally publishedYes

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Resistin
Colectomy
Adiponectin
Serum
Hand-Assisted Laparoscopy
Physiological Stress
Advanced Glycosylation End Product-Specific Receptor
Analysis of Variance
Hand
Enzyme-Linked Immunosorbent Assay
Wounds and Injuries

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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Serum adiponectin, resistin, and circulating soluble receptor for advanced glycation end products in colectomy patients. / Asgeirsson, Theodor; Zhang, Sen; Khoo, Sok Kean; Resau, James H.; Dujovny, Nadav; Senagore, Anthony J.

In: Mediators of Inflammation, Vol. 2011, 916807, 2011.

Research output: Contribution to journalArticle

Asgeirsson, Theodor ; Zhang, Sen ; Khoo, Sok Kean ; Resau, James H. ; Dujovny, Nadav ; Senagore, Anthony J. / Serum adiponectin, resistin, and circulating soluble receptor for advanced glycation end products in colectomy patients. In: Mediators of Inflammation. 2011 ; Vol. 2011.
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