Serum and urinary immunoglobulin in the rat model of acute urinary tract infection

H. J. Herrera; C. P. Davis; M. S. Cohen; M. D. Anderson; M. M. Warren

doi:10.1016/0024-3205(91)90161-4

Serum and urinary immunoglobulin in the rat model of acute urinary tract infection

H. J. Herrera, C. P. Davis, M. S. Cohen, M. D. Anderson, M. M. Warren

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Total levels of urine and serum immunoglobulin IgM, IgG and IgA, and the E. coli-specific bacterial immunoglobulin response were determined by enzyme-linked immunosorbant assay (ELISA) in a rat model of acute urinary tract infection. High levels of urinary IgM were detected as early as day 3 post infection and then decreased to statistically insignificant levels. Peak levels of IgG occurred in the serum and urine on day 14. Urine and serum IgA levels remained low throughout the study period. The results demonstrate that in the rat model of acute urinary tract infection, IgM appears first in the urine and serum, and rapidly decreases. IgG then appears in the serum and urine followed by a late E. coli-specific immunoglobulin serum and urine response. Also, a non-specific component of the immunoglobulin response was noted in both the serum and urine. In the rat, IgA appears to play little or no role in the urine or in the serum response to the infection.

Original language	English (US)
Pages (from-to)	2047-2056
Number of pages	10
Journal	Life Sciences
Volume	48
Issue number	21
DOIs	https://doi.org/10.1016/0024-3205(91)90161-4
State	Published - 1991

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/0024-3205(91)90161-4

Cite this

@article{e1d3d029856a460a927736ee9d548438,

title = "Serum and urinary immunoglobulin in the rat model of acute urinary tract infection",

abstract = "Total levels of urine and serum immunoglobulin IgM, IgG and IgA, and the E. coli-specific bacterial immunoglobulin response were determined by enzyme-linked immunosorbant assay (ELISA) in a rat model of acute urinary tract infection. High levels of urinary IgM were detected as early as day 3 post infection and then decreased to statistically insignificant levels. Peak levels of IgG occurred in the serum and urine on day 14. Urine and serum IgA levels remained low throughout the study period. The results demonstrate that in the rat model of acute urinary tract infection, IgM appears first in the urine and serum, and rapidly decreases. IgG then appears in the serum and urine followed by a late E. coli-specific immunoglobulin serum and urine response. Also, a non-specific component of the immunoglobulin response was noted in both the serum and urine. In the rat, IgA appears to play little or no role in the urine or in the serum response to the infection.",

author = "Herrera, {H. J.} and Davis, {C. P.} and Cohen, {M. S.} and Anderson, {M. D.} and Warren, {M. M.}",

year = "1991",

doi = "10.1016/0024-3205(91)90161-4",

language = "English (US)",

volume = "48",

pages = "2047--2056",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "21",

}

TY - JOUR

T1 - Serum and urinary immunoglobulin in the rat model of acute urinary tract infection

AU - Herrera, H. J.

AU - Davis, C. P.

AU - Cohen, M. S.

AU - Anderson, M. D.

AU - Warren, M. M.

PY - 1991

Y1 - 1991

N2 - Total levels of urine and serum immunoglobulin IgM, IgG and IgA, and the E. coli-specific bacterial immunoglobulin response were determined by enzyme-linked immunosorbant assay (ELISA) in a rat model of acute urinary tract infection. High levels of urinary IgM were detected as early as day 3 post infection and then decreased to statistically insignificant levels. Peak levels of IgG occurred in the serum and urine on day 14. Urine and serum IgA levels remained low throughout the study period. The results demonstrate that in the rat model of acute urinary tract infection, IgM appears first in the urine and serum, and rapidly decreases. IgG then appears in the serum and urine followed by a late E. coli-specific immunoglobulin serum and urine response. Also, a non-specific component of the immunoglobulin response was noted in both the serum and urine. In the rat, IgA appears to play little or no role in the urine or in the serum response to the infection.

AB - Total levels of urine and serum immunoglobulin IgM, IgG and IgA, and the E. coli-specific bacterial immunoglobulin response were determined by enzyme-linked immunosorbant assay (ELISA) in a rat model of acute urinary tract infection. High levels of urinary IgM were detected as early as day 3 post infection and then decreased to statistically insignificant levels. Peak levels of IgG occurred in the serum and urine on day 14. Urine and serum IgA levels remained low throughout the study period. The results demonstrate that in the rat model of acute urinary tract infection, IgM appears first in the urine and serum, and rapidly decreases. IgG then appears in the serum and urine followed by a late E. coli-specific immunoglobulin serum and urine response. Also, a non-specific component of the immunoglobulin response was noted in both the serum and urine. In the rat, IgA appears to play little or no role in the urine or in the serum response to the infection.

UR - http://www.scopus.com/inward/record.url?scp=0025825676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025825676&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(91)90161-4

DO - 10.1016/0024-3205(91)90161-4

M3 - Article

C2 - 2034034

AN - SCOPUS:0025825676

SN - 0024-3205

VL - 48

SP - 2047

EP - 2056

JO - Life Sciences

JF - Life Sciences

IS - 21

ER -

Serum and urinary immunoglobulin in the rat model of acute urinary tract infection

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this