Serum concentrations of laminin and fibronectin in patients with acute coronary syndromes

Xiaojun Bai, Aiqun Ma, Yutao Xi, Geru Wu, Bingwen Ren

Research output: Contribution to journalArticle

Abstract

Objective: To study the serum laminin (LN) and fibronectin (FN) changes in acute coronary syndromes (ACS), and explore the role of them in assessing the severity of ACS. Methods: This study included 46 ACS patients [25 with acute myocardial infarction (AMI) and 21 with unstable angina (UA)], 51 stable angina (SA) patients and 47 people without CHD as controls. Serum levels of LN, FN, fibrinogen and blood fat were assessed. Coronary angiography were performed on 49 of them. Results: The serum concentration of LN was lower in ACS patients [(85.20±27.57) ng/mL], higher in SA patients [(116.80±28.80) ng/mL] as compared to that in the control group [(100.06±29.96) ng/mL], with significant difference among the groups (P<0.05). No difference was found in FN among the three groups. However, the subgroup analysis in the group with ACS showed that the serum concentration of FN was significantly higher in UA patients [(229.60±121.39) μ;g/mL], and lower in AMI patients [(108.31±47.12) μg/mL]. The serum LN and FN concentration could respectively enter the logistic regression equations of ACS patients and US patients. Neither LN nor FN concentration was correlated with narrowing of coronary artery of angiography. Conclusion: Serum LN and FN level may be a useful indicator for stability of atherosclerosis plaque in coronary arterial disease patients, but could not predict the extent of narrowing in coronary angiography.

Original languageEnglish (US)
Pages (from-to)88-91
Number of pages4
JournalAcademic Journal of Xi'an Jiaotong University
Volume20
Issue number2
StatePublished - May 1 2008
Externally publishedYes

Fingerprint

Laminin
Acute Coronary Syndrome
Fibronectins
Angiography
Serum
Coronary Angiography
Stable Angina
Unstable Angina
Myocardial Infarction
Fibrinogen
Logistics
Blood
Fats
Coronary Disease
Atherosclerosis
Coronary Vessels
Logistic Models
Control Groups

Keywords

  • Acute coronary syndrome
  • Angiography
  • Fibronectin
  • Laminin

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Serum concentrations of laminin and fibronectin in patients with acute coronary syndromes. / Bai, Xiaojun; Ma, Aiqun; Xi, Yutao; Wu, Geru; Ren, Bingwen.

In: Academic Journal of Xi'an Jiaotong University, Vol. 20, No. 2, 01.05.2008, p. 88-91.

Research output: Contribution to journalArticle

Bai, Xiaojun ; Ma, Aiqun ; Xi, Yutao ; Wu, Geru ; Ren, Bingwen. / Serum concentrations of laminin and fibronectin in patients with acute coronary syndromes. In: Academic Journal of Xi'an Jiaotong University. 2008 ; Vol. 20, No. 2. pp. 88-91.
@article{96ce42b907ee48aa9d93e55da6da0bf0,
title = "Serum concentrations of laminin and fibronectin in patients with acute coronary syndromes",
abstract = "Objective: To study the serum laminin (LN) and fibronectin (FN) changes in acute coronary syndromes (ACS), and explore the role of them in assessing the severity of ACS. Methods: This study included 46 ACS patients [25 with acute myocardial infarction (AMI) and 21 with unstable angina (UA)], 51 stable angina (SA) patients and 47 people without CHD as controls. Serum levels of LN, FN, fibrinogen and blood fat were assessed. Coronary angiography were performed on 49 of them. Results: The serum concentration of LN was lower in ACS patients [(85.20±27.57) ng/mL], higher in SA patients [(116.80±28.80) ng/mL] as compared to that in the control group [(100.06±29.96) ng/mL], with significant difference among the groups (P<0.05). No difference was found in FN among the three groups. However, the subgroup analysis in the group with ACS showed that the serum concentration of FN was significantly higher in UA patients [(229.60±121.39) μ;g/mL], and lower in AMI patients [(108.31±47.12) μg/mL]. The serum LN and FN concentration could respectively enter the logistic regression equations of ACS patients and US patients. Neither LN nor FN concentration was correlated with narrowing of coronary artery of angiography. Conclusion: Serum LN and FN level may be a useful indicator for stability of atherosclerosis plaque in coronary arterial disease patients, but could not predict the extent of narrowing in coronary angiography.",
keywords = "Acute coronary syndrome, Angiography, Fibronectin, Laminin",
author = "Xiaojun Bai and Aiqun Ma and Yutao Xi and Geru Wu and Bingwen Ren",
year = "2008",
month = "5",
day = "1",
language = "English (US)",
volume = "20",
pages = "88--91",
journal = "Academic Journal of Xi'an Jiaotong University",
issn = "1671-8267",
publisher = "Xi'an Medical University",
number = "2",

}

TY - JOUR

T1 - Serum concentrations of laminin and fibronectin in patients with acute coronary syndromes

AU - Bai, Xiaojun

AU - Ma, Aiqun

AU - Xi, Yutao

AU - Wu, Geru

AU - Ren, Bingwen

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Objective: To study the serum laminin (LN) and fibronectin (FN) changes in acute coronary syndromes (ACS), and explore the role of them in assessing the severity of ACS. Methods: This study included 46 ACS patients [25 with acute myocardial infarction (AMI) and 21 with unstable angina (UA)], 51 stable angina (SA) patients and 47 people without CHD as controls. Serum levels of LN, FN, fibrinogen and blood fat were assessed. Coronary angiography were performed on 49 of them. Results: The serum concentration of LN was lower in ACS patients [(85.20±27.57) ng/mL], higher in SA patients [(116.80±28.80) ng/mL] as compared to that in the control group [(100.06±29.96) ng/mL], with significant difference among the groups (P<0.05). No difference was found in FN among the three groups. However, the subgroup analysis in the group with ACS showed that the serum concentration of FN was significantly higher in UA patients [(229.60±121.39) μ;g/mL], and lower in AMI patients [(108.31±47.12) μg/mL]. The serum LN and FN concentration could respectively enter the logistic regression equations of ACS patients and US patients. Neither LN nor FN concentration was correlated with narrowing of coronary artery of angiography. Conclusion: Serum LN and FN level may be a useful indicator for stability of atherosclerosis plaque in coronary arterial disease patients, but could not predict the extent of narrowing in coronary angiography.

AB - Objective: To study the serum laminin (LN) and fibronectin (FN) changes in acute coronary syndromes (ACS), and explore the role of them in assessing the severity of ACS. Methods: This study included 46 ACS patients [25 with acute myocardial infarction (AMI) and 21 with unstable angina (UA)], 51 stable angina (SA) patients and 47 people without CHD as controls. Serum levels of LN, FN, fibrinogen and blood fat were assessed. Coronary angiography were performed on 49 of them. Results: The serum concentration of LN was lower in ACS patients [(85.20±27.57) ng/mL], higher in SA patients [(116.80±28.80) ng/mL] as compared to that in the control group [(100.06±29.96) ng/mL], with significant difference among the groups (P<0.05). No difference was found in FN among the three groups. However, the subgroup analysis in the group with ACS showed that the serum concentration of FN was significantly higher in UA patients [(229.60±121.39) μ;g/mL], and lower in AMI patients [(108.31±47.12) μg/mL]. The serum LN and FN concentration could respectively enter the logistic regression equations of ACS patients and US patients. Neither LN nor FN concentration was correlated with narrowing of coronary artery of angiography. Conclusion: Serum LN and FN level may be a useful indicator for stability of atherosclerosis plaque in coronary arterial disease patients, but could not predict the extent of narrowing in coronary angiography.

KW - Acute coronary syndrome

KW - Angiography

KW - Fibronectin

KW - Laminin

UR - http://www.scopus.com/inward/record.url?scp=44349100354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44349100354&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:44349100354

VL - 20

SP - 88

EP - 91

JO - Academic Journal of Xi'an Jiaotong University

JF - Academic Journal of Xi'an Jiaotong University

SN - 1671-8267

IS - 2

ER -