Serum ferritin assay and bone-marrow iron stores in patients on maintenance hemodialysis

J. D. Bell; W. R. Kincaid; R. G. Morgan; H. Bunce IIIrd; J. B. Alperin; H. E. Sarles; A. R. Remmers

doi:10.1038/ki.1980.27

Serum ferritin assay and bone-marrow iron stores in patients on maintenance hemodialysis

J. D. Bell, W. R. Kincaid, R. G. Morgan, H. Bunce IIIrd, J. B. Alperin, H. E. Sarles, A. R. Remmers

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Fifty five patients on maintenance hemodialysis underwent bone marrow aspirations for evaluation of iron stores that were to be compared to concomitant measurements of hematocrit, red blood cell volume, serum iron concentration, total iron binding capacity, transferrin saturation, and serum ferritin concentration. In 42 patients (76.4%), the bone-marrow iron stores were found to be absent or deficient. Mean hematocrit for the total group was 26.4%, and red blood cell volume measurement showed a mean value of 41.1% of predicted normal. Results also indicated that serum ferritin was the best predictor of iron storage levels, with diagnostic thresholds of 80 to 350 ng/ml derived from statistical analysis of the data. Other hematologic parameters studied had significantly less correlation with bone-marrow iron stores.

Original language	English (US)
Pages (from-to)	237-241
Number of pages	5
Journal	Kidney International
Volume	17
Issue number	2
DOIs	https://doi.org/10.1038/ki.1980.27
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

Nephrology

Access to Document

10.1038/ki.1980.27

Cite this

@article{d530e173fa494d00b25a74aa22241899,

title = "Serum ferritin assay and bone-marrow iron stores in patients on maintenance hemodialysis",

abstract = "Fifty five patients on maintenance hemodialysis underwent bone marrow aspirations for evaluation of iron stores that were to be compared to concomitant measurements of hematocrit, red blood cell volume, serum iron concentration, total iron binding capacity, transferrin saturation, and serum ferritin concentration. In 42 patients (76.4%), the bone-marrow iron stores were found to be absent or deficient. Mean hematocrit for the total group was 26.4%, and red blood cell volume measurement showed a mean value of 41.1% of predicted normal. Results also indicated that serum ferritin was the best predictor of iron storage levels, with diagnostic thresholds of 80 to 350 ng/ml derived from statistical analysis of the data. Other hematologic parameters studied had significantly less correlation with bone-marrow iron stores.",

author = "Bell, {J. D.} and Kincaid, {W. R.} and Morgan, {R. G.} and {Bunce IIIrd}, H. and Alperin, {J. B.} and Sarles, {H. E.} and Remmers, {A. R.}",

year = "1980",

doi = "10.1038/ki.1980.27",

language = "English (US)",

volume = "17",

pages = "237--241",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Nature Publishing Group",

number = "2",

}

TY - JOUR

T1 - Serum ferritin assay and bone-marrow iron stores in patients on maintenance hemodialysis

AU - Bell, J. D.

AU - Kincaid, W. R.

AU - Morgan, R. G.

AU - Bunce IIIrd, H.

AU - Alperin, J. B.

AU - Sarles, H. E.

AU - Remmers, A. R.

PY - 1980

Y1 - 1980

N2 - Fifty five patients on maintenance hemodialysis underwent bone marrow aspirations for evaluation of iron stores that were to be compared to concomitant measurements of hematocrit, red blood cell volume, serum iron concentration, total iron binding capacity, transferrin saturation, and serum ferritin concentration. In 42 patients (76.4%), the bone-marrow iron stores were found to be absent or deficient. Mean hematocrit for the total group was 26.4%, and red blood cell volume measurement showed a mean value of 41.1% of predicted normal. Results also indicated that serum ferritin was the best predictor of iron storage levels, with diagnostic thresholds of 80 to 350 ng/ml derived from statistical analysis of the data. Other hematologic parameters studied had significantly less correlation with bone-marrow iron stores.

AB - Fifty five patients on maintenance hemodialysis underwent bone marrow aspirations for evaluation of iron stores that were to be compared to concomitant measurements of hematocrit, red blood cell volume, serum iron concentration, total iron binding capacity, transferrin saturation, and serum ferritin concentration. In 42 patients (76.4%), the bone-marrow iron stores were found to be absent or deficient. Mean hematocrit for the total group was 26.4%, and red blood cell volume measurement showed a mean value of 41.1% of predicted normal. Results also indicated that serum ferritin was the best predictor of iron storage levels, with diagnostic thresholds of 80 to 350 ng/ml derived from statistical analysis of the data. Other hematologic parameters studied had significantly less correlation with bone-marrow iron stores.

UR - http://www.scopus.com/inward/record.url?scp=0018833217&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018833217&partnerID=8YFLogxK

U2 - 10.1038/ki.1980.27

DO - 10.1038/ki.1980.27

M3 - Article

C2 - 7382271

AN - SCOPUS:0018833217

SN - 0085-2538

VL - 17

SP - 237

EP - 241

JO - Kidney International

JF - Kidney International

IS - 2

ER -

Serum ferritin assay and bone-marrow iron stores in patients on maintenance hemodialysis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this