Serum levels of neurofilament-h are elevated in patients suffering from severe burns

Joshua W. Gatson, Ming Mei Liu, Fernando A. Rivera-Chavez, Joseph P. Minei, Steven Wolf

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In previous studies, after injury, burn patients experienced an increase in neuro-inflammation, edema, and neuronal cell death. As demonstrated in other brain injury models, fluid-based biomarkers such as phosphorylated neurofilament-H (pNFL-H) have been shown to correlate with injury severity. In this study the authors hypothesized that burn-injured patients have an increase in pNFL-H in the blood during the acute and chronic time-points after injury. In this prospective clinical study, blood (8 cc) was collected from burn patients (n = 36; TBSA 10-60%) at Parkland hospital, Dallas, Texas, on days 1, 7, and 14 after injury. The serum levels of pNFL-H were measured using the enzyme-linked immunoassay. Compared to noninjured controls, the burn patients exhibited a significant increase in the serum levels of pNFL-H on days 7 (P <.0001) and 14 (P <.0001) after burn injury. No significant increase was observed on day 1 (P <.07) after injury. A positive correlation between TBSA and pNFL-H levels was observed for day 14 (r =.55; P <.03). Additionally, using the receiver operating characteristic analysis, the authors determined the area under the curve was 98% for both day 7 and 14. In conclusion, this study describes the serum profile of pNFL-H in patients suffering from severe burns during the acute (day 1) and chronic (days 7 and 14) time-points. These results suggest that detection of pNFL-H may be useful in determining which individuals suffer from nerve cell degeneration after burn.

Original languageEnglish (US)
Pages (from-to)545-550
Number of pages6
JournalJournal of Burn Care and Research
Volume36
Issue number5
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Rehabilitation

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