Serum levels of tumor necrosis factor-α, interleukin-1, and interleukin-6 in hemorrhagic fever with renal syndrome

T. Krakauer, James LeDuc, H. Krakauer

Research output: Contribution to journalArticle

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Abstract

Hemorrhagic fever with renal syndrome is an acute viral disease caused by hantavirus. On the basis of clinical observation, the illness is divided into five sequential stages: febrile, hypotensive, oliguric, diuretic, and convalescent. Because interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) are mediators responsible for fever, septic shock, and acute phase protein induction, we examined, using ELISA, the presence of these three cytokines in 276 sera collected during the Korean Conflict from 110 patients. Detectable levels (> 20 pg/ml) of TNF-α; IL-1β, and IL-6 occurred in 14, 14, and 33% of these samples, respectively. There was a significant correlation between serum levels of IL-1β and TNF-α (r = 0.66, p < 0.001), IL-1β and IL-6 (r = 0.59, p < 0.001), and IL-6 and TNF-α (r = 0.71, p < 0.001). The pathophysiologic processes of HFRS do not have clear or consistent correlations with alterations in the levels of the cytokines studied.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalViral Immunology
Volume8
Issue number2
StatePublished - 1995
Externally publishedYes

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Hemorrhagic Fever with Renal Syndrome
Interleukin-1
Interleukin-6
Tumor Necrosis Factor-alpha
Serum
Korean War
Fever
Cytokines
Hantavirus
Acute-Phase Proteins
Acute Disease
Virus Diseases
Septic Shock
Diuretics
Enzyme-Linked Immunosorbent Assay
Observation

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Serum levels of tumor necrosis factor-α, interleukin-1, and interleukin-6 in hemorrhagic fever with renal syndrome. / Krakauer, T.; LeDuc, James; Krakauer, H.

In: Viral Immunology, Vol. 8, No. 2, 1995, p. 75-79.

Research output: Contribution to journalArticle

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