Serum proteins are known to extravasate into the brain parenchyma in senile and presenile dementia (Glenner: Hum. Pathol. 16:433–435, 1986; Wisniewski and Kozlowski: Ann. NY Acad. Sci. 396:119–129, 1982). We have recently demonstrated that human serum Cohn fraction IV (alpha‐globulin enriched) inhibits ligand binding at putative dopamine and serotonin2 receptors labeled by [3H]spiroperidol in human brain (Andorn, Pappolla, Fox, Klemens, and Martello: Proc. Natl. Acad. Sci. USA 83:4572–4575, 1986). We now demonstrate that serum proteins can be identified in the neuropil and in neuronal cell bodies in normal aged brain, that alpha‐globulin‐enriched fractions inhibit ligand binding at alpha2‐adrenergic and muscarinic binding sites in human brain as well, and that serum proteins can be identified within neuronal cytoplasm and axons.
- Blood brain barrier
- Neurotransmitter receptors
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience