Serum protein leakage in aged human brain and inhibition of ligand binding at alpha2‐ adrenergic and cholinergic binding sites

Miguel A. Pappolla, Anne C. Andorn

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Serum proteins are known to extravasate into the brain parenchyma in senile and presenile dementia (Glenner: Hum. Pathol. 16:433–435, 1986; Wisniewski and Kozlowski: Ann. NY Acad. Sci. 396:119–129, 1982). We have recently demonstrated that human serum Cohn fraction IV (alpha‐globulin enriched) inhibits ligand binding at putative dopamine and serotonin2 receptors labeled by [3H]spiroperidol in human brain (Andorn, Pappolla, Fox, Klemens, and Martello: Proc. Natl. Acad. Sci. USA 83:4572–4575, 1986). We now demonstrate that serum proteins can be identified in the neuropil and in neuronal cell bodies in normal aged brain, that alpha‐globulin‐enriched fractions inhibit ligand binding at alpha2‐adrenergic and muscarinic binding sites in human brain as well, and that serum proteins can be identified within neuronal cytoplasm and axons.

Original languageEnglish (US)
Pages (from-to)82-89
Number of pages8
JournalSynapse
Volume1
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

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Keywords

  • Aging
  • Blood brain barrier
  • Dementia
  • Neurotransmitter receptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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