Serum soluble Fas levels in preeclampsia

Chaur Dong Hsu, Hassan Harirah, Hasan Basherra, Gil Mor

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Objective: To determine if serum soluble Fas levels are altered in women with preeclampsia. Methods: Thirty-four pregnant women with preeclampsia and 34 normotensive pregnant women were studied. Subjects were matched as much as possible for demographics. Preeclampsia was defined as proteinuric hypertension. Serum soluble Fas levels were measured by enzyme-linked immunoassay. Two-tailed Student t test, χ2 test, Pearson correlation coefficients, and analysis of variance with post hoc test were used for statistical analyses. Results: Mean serum soluble Fas levels were significantly higher in preeclamptic than normotensive women (10.59 ± 0.68 U/mL versus 5.65 ± 0.35 U/mL, P < .001). Conclusion: Elevated serum soluble Fas is associated with preeclampsia. Such elevation might indicate protection of maternal T-lymphocyte apoptosis and consequently lead to the maternal immune intolerance noted in preeclampsia.

Original languageEnglish (US)
Pages (from-to)530-532
Number of pages3
JournalObstetrics and gynecology
Volume97
Issue number4
DOIs
StatePublished - Apr 5 2001
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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