Sesame oil consumption exerts a beneficial effect on endothelial function in hypertensive men.

Kalliopi Karatzi, Kimon Stamatelopoulos, Maritta Lykka, Pigi Mantzouratou, Sofia Skalidi, Nikolaos Zakopoulos, Christos Papamichael, Labros S. Sidossis

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The aim of the study was to investigate the effects of sesame oil on endothelial function and to detect the underlying mechanisms, both in the postprandial state and after long-term consumption. We enrolled 30 hypertensive men in a two-phase study. In the first phase, 26 volunteers consumed 35 g of either sesame oil or control oil. Endothelial function, inflammatory activation and nitric oxide syntase (NOS) inhibition was assessed after a 12-hour fast and 2 hours after consumption of an oil-containing standardized meal. In the second phase, 30 volunteers consumed 35 g of sesame oil or control oil daily for 2 months and the above-mentioned parameters were assessed at baseline, 15, 30 and 60 days. Methods: Endothelial function was estimated by endothelium-dependent FMD (flow-mediated dilatation) of the brachial artery. Flow-mediated dilatation (FMD) improved significantly both after acute (p = 0.001) and long-term sesame oil consumption (p = 0.015, p = 0.005 and p = 0.011 for 15, 30 and 60 days respectively). Intracellular adhesion molecule (ICAM) levels decreased significantly after only 60 days of daily sesame oil intake (p = 0.014). By contrast, no changes were observed in the control group in either phase of the study. This is the first study to show that sesame oil consumption exerts a beneficial effect on endothelial function and this effect is sustained with long-term daily use.

Original languageEnglish (US)
Pages (from-to)202-208
Number of pages7
JournalEuropean Journal of Preventive Cardiology
Volume20
Issue number2
DOIs
StatePublished - Apr 2013
Externally publishedYes

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Sesame Oil
Oils
Dilatation
Volunteers
Brachial Artery
Endothelium
Meals
Nitric Oxide
Control Groups

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Epidemiology

Cite this

Karatzi, K., Stamatelopoulos, K., Lykka, M., Mantzouratou, P., Skalidi, S., Zakopoulos, N., ... Sidossis, L. S. (2013). Sesame oil consumption exerts a beneficial effect on endothelial function in hypertensive men. European Journal of Preventive Cardiology, 20(2), 202-208. https://doi.org/10.1177/2047487312437625

Sesame oil consumption exerts a beneficial effect on endothelial function in hypertensive men. / Karatzi, Kalliopi; Stamatelopoulos, Kimon; Lykka, Maritta; Mantzouratou, Pigi; Skalidi, Sofia; Zakopoulos, Nikolaos; Papamichael, Christos; Sidossis, Labros S.

In: European Journal of Preventive Cardiology, Vol. 20, No. 2, 04.2013, p. 202-208.

Research output: Contribution to journalArticle

Karatzi, K, Stamatelopoulos, K, Lykka, M, Mantzouratou, P, Skalidi, S, Zakopoulos, N, Papamichael, C & Sidossis, LS 2013, 'Sesame oil consumption exerts a beneficial effect on endothelial function in hypertensive men.', European Journal of Preventive Cardiology, vol. 20, no. 2, pp. 202-208. https://doi.org/10.1177/2047487312437625
Karatzi, Kalliopi ; Stamatelopoulos, Kimon ; Lykka, Maritta ; Mantzouratou, Pigi ; Skalidi, Sofia ; Zakopoulos, Nikolaos ; Papamichael, Christos ; Sidossis, Labros S. / Sesame oil consumption exerts a beneficial effect on endothelial function in hypertensive men. In: European Journal of Preventive Cardiology. 2013 ; Vol. 20, No. 2. pp. 202-208.
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