Seventy-four-year-old woman with myelodysplastic syndrome and splenomegaly

Alison Motosue, Jack Alperin, Mohamed T. Elghetany, Rana Bonds

Research output: Contribution to journalArticlepeer-review


We present a 74-year-old woman with a recent diagnosis of myelodysplastic syndrome who presented with left upper quadrant abdominal pain and fatigue with significant splenomegaly, anemia, and thrombocytopenia. She underwent splenectomy and bone marrow biopsy. Pathology of both spleen and bone marrow revealed an unusual diagnosis. A review of the differential diagnosis, laboratory tests, nature of the underlying disease, and treatment are provided.

Original languageEnglish (US)
Pages (from-to)252-257
Number of pages6
JournalAllergy and Asthma Proceedings
Issue number3
StatePublished - May 2010


  • D816V
  • Hematologic non-mast cell lineage disease
  • Hypersplenism
  • Mast cells
  • Mastocytosis
  • Myelodysplastic syndrome
  • Splenomegaly
  • Systemic mastocytosis with associated clonal
  • Urticaria pigmentosa

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


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